⚠️ CAUTION — trust gate(s) tripped; review before using:
- Affinage's own head-to-head self-evaluation scored this record
pairwise = tie(notwin) vs the curated UniProt reference — treat the narrative with extra scepticism.
ADISSP (C20orf27) is an adipose-specific secreted signaling protein that functions as an adipokine coupling adrenergic input to thermogenesis and glucose homeostasis PMID:36496438. Its expression is enriched in brown adipose tissue and its secretion is stimulated by β3-adrenergic activation PMID:36496438; once released, it binds a surface receptor on adipocytes and activates protein kinase A independently of β-adrenergic signaling to drive white adipose tissue browning PMID:36496438. Adipose-specific knockout impairs WAT browning and renders mice susceptible to high-fat diet-induced obesity and hyperglycemia, establishing ADISSP as a required upstream regulator of thermogenesis and glucose handling PMID:36496438. Recombinant ADISSP additionally activates insulin-independent Akt signaling in white fat to promote glucose disposal and normalize hyperglycemia in type 1 and type 2 diabetic models PMID:42030391. In cancer settings, ADISSP interacts with the catalytic subunit of protein phosphatase 1 (PP1c) and promotes colorectal cancer cell proliferation through activation of the TGFβR-TAK1-NFκB cascade PMID:32024300. The identity of its adipocyte surface receptor and the molecular route from receptor engagement to PKA and Akt activation have not been characterized in the available corpus.
Recorded for reference. The AIGR evaluation found this grounding is coarse (collapses to general parents) and can contradict the narrative — do not import these GO ids directly; re-ground from the narrative + PMIDs.
| Year | Confidence | Finding | PMIDs | Journal |
|---|---|---|---|---|
| 2022 | Medium | Adissp (C20orf27/FLJ20550) is an adipose-secreted signaling protein whose expression is adipose-specific and highly enriched in brown adipose tissue (BAT); its secretion is stimulated by β3-adrenergic activation. | PMID:36496438 | Nature Communications |
| 2022 | Medium | Adissp binds to a putative receptor on the adipocyte surface and activates protein kinase A (PKA) independently of β-adrenergic signaling, promoting white adipose tissue (WAT) browning/thermogenesis. | PMID:36496438 | Nature Communications |
| 2022 | High | Adipose-specific Adissp knockout mice are defective in WAT browning and are susceptible to high-fat diet-induced obesity and hyperglycemia, establishing Adissp as a required upstream regulator of thermogenesis and glucose homeostasis. | PMID:36496438 | Nature Communications |
| 2026 | Medium | Recombinant Adissp (rAdissp) protein activates insulin-independent Akt signaling in white fat to stimulate glucose disposal, normalizing hyperglycemia in both type 1 and type 2 diabetic mouse models. | PMID:42030391 | Science Advances |
| 2020 | Medium | C20orf27 (ADISSP) promotes colorectal cancer cell growth and proliferation by interacting with PP1c (the catalytic subunit of type 1 phosphatase) and activating the TGFβR-TAK1-NFκB signaling cascade; NFκB inhibition reverses this effect. | PMID:32024300 | Cancers |
| 2025 | Low | C20orf27 (ADISSP) promotes hepatocellular carcinoma cell proliferation and migration by regulating cyclin-related proteins (MDM2, PCNA, Cyclin E1, CDK2, p-Rb) and acts upstream of NT5E as a downstream target. | PMID:40690096 | Discover Oncology |
| 2025 | Low | C20orf27 (ADISSP) mediates colorectal cancer cell proliferation through XBP1 signaling under normal lipid conditions, but switches to promoting metastasis via MST1 signaling under high-lipid conditions, demonstrating context-dependent pathway utilization. | PMID:40876696 | Cellular Signalling |