Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

PMID:11399750

Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump.

V-ATPase E subunit directly interacts with aldolase (ALDOC); interaction confirmed by yeast two-hybrid and co-immunoprecipitation; aldolase deficiency causes V1-V0 dissociation, suggesting coupling of glycolysis to V-ATPase activity.

PMID:16169070

A human protein-protein interaction network: a resource for annotating the proteome.

ATP6V1E1 detected in high-throughput interactome study.

PMID:17897319

Integral and associated lysosomal membrane proteins.

ATP6V1E1 detected in lysosomal membrane proteomics study.

PMID:19056867

Large-scale proteomics and phosphoproteomics of urinary exosomes.

ATP6V1E1 detected in urinary exosomes by mass spectrometry.

PMID:19199708

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).

ATP6V1E1 detected in parotid gland exosome proteome.

PMID:20717956

Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts.

V-ATPase E subunit interacts with RAB11B; RAB11B/Rip11 regulate acidosis-induced trafficking of V-ATPase to apical membrane in salivary duct cells.

PMID:21784977

Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation.

Paper concerns tristetraprolin/CCL3 mRNA regulation; no evidence for ATP6V1E1 involvement. Annotation likely a curation error.

PMID:22053050

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.

V-ATPase V1 domain (including E subunit) interacts with Ragulator on lysosomes; V-ATPase ATP hydrolysis required for amino acid-induced mTORC1 activation.

PMID:22982048

Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts.

V-ATPase broadly required for lysosomal-mediated macroautophagy.

PMID:28065471

Mutations in ATP6V1E1 or ATP6V1A cause autosomal-recessive cutis laxa.

Loss-of-function variants in ATP6V1E1 cause ARCL2C; P128 and W212 variants identified; high expression in skin; disease mechanism involves V-ATPase dysfunction affecting connective tissue.

PMID:29993276

H(+)-ATPase B1 subunit localizes to thick ascending limb and distal convoluted tubule of rodent and human kidney.

V-ATPase (including E subunit) localizes to apical membrane of thick ascending limb and distal convoluted tubule in human kidney.

PMID:32001091

Structure and Roles of V-type ATPases.

Comprehensive review of V-ATPase structure, roles in organellar acidification, and disease relevance.

PMID:33065002

Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

Cryo-EM structures of complete human V-ATPase; E1 subunit resolved in three peripheral stalk EG heterodimers at near-atomic resolution.

PMID:35271311

OpenCell: Endogenous tagging for the cartography of human cellular organization.

ATP6V1E1 localization mapped by endogenous tagging.

PMID:8250920

Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase.

Human V-ATPase E subunit cloned from osteoclastoma; ubiquitous expression; part of the proton-transporting V-type ATPase complex.

Reactome:R-HSA-1222516

Intraphagosomal pH is lowered to 5 by V-ATPase

Reactome:R-HSA-5252133

ATP6AP1 binds V-ATPase

Reactome:R-HSA-74723

Endosome acidification

Reactome:R-HSA-917841

Acidification of Tf:TfR1 containing endosome

Reactome:R-HSA-9639286

RRAGC,D exchanges GTP for GDP

Reactome:R-HSA-9640167

RRAGA,B exchanges GDP for GTP

Reactome:R-HSA-9640168

v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine

Reactome:R-HSA-9640175

v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine

Reactome:R-HSA-9640195

RRAGA,B hydrolyzes GTP

Reactome:R-HSA-9645598

RRAGC,D hydrolyzes GTP

Reactome:R-HSA-9645608

v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1

Reactome:R-HSA-9646468

mTORC1 binds RHEB:GTP

Reactome:R-HSA-9858923

MITF-M-dependent ATP6V1E1 gene expression

MITF-M transcription factor regulates ATP6V1E1 expression in the context of lysosome biogenesis.