Cadmus (cdm/Imp13) evidence notes

Q9VEC5 is the 971-residue product of current FlyBase FBgn0261532, formerly CG7212/imp13. PA and PB encode identical proteins (AAF55502/NP_650682 and AGB96076/NP_001262696), as recorded in the saved FlyBase report. The current symbol cdm is retained rather than replacing it with an older literature synonym. FlyBase.

PMID:20122403(https://pubmed.ncbi.nlm.nih.gov/20122403/) explicitly reports a “Drosophila Imp13-Mago-Y14 complex” and a “human Imp13 bound to RanGTP” structure. This identifies direct fly import-cargo recognition and a conserved mechanism; it does not identify the particular cargo responsible for every synaptic phenotype. The cache is abstract-only, so no claims about uninspected residue-level experiments are made. The fly structural observation supplies independent support for the PAINT transport assignments.

PMID:11447110(https://pubmed.ncbi.nlm.nih.gov/11447110/) reports “Imp13 also shows export activity towards the translation initiation factor eIF1A”. Export in the fly is a conserved importin-13 inference, supported by its diagnostic identity and the phylogenetic annotation, not a claimed direct Drosophila eIF1A transport assay. QuickGO lookup of the older Ran-binding identifier GO:0008536 resolved to GO:0031267; the existing small-GTPase-binding identifier is retained.

PMID:19403829(https://pmc.ncbi.nlm.nih.gov/articles/PMC4011492/) is cached with full text and establishes the connection between CG7212 mutations, genomic rescue, visual phenotypes and postsynaptic control of presynaptic release. The decisive localization qualification is “Imp13 expression only in the muscle nuclei but not at the synapse” for the rescuing genomic construct; NMJ synaptic fluorescence occurred under overexpression. Accordingly, the process-derived synapse IEA is over-annotated; it is not evidence against the observed synaptic physiological role. Nuclear/perinuclear localization and transport are core; visual and transmission phenotypes are non-core.

PMID:14504225(https://pubmed.ncbi.nlm.nih.gov/14504225/) remains abstract-only after full-text retrieval was attempted. The 2009 follow-up independently connects the mutant locus to Imp13 and rescues the visual phenotype, so there is no basis to overturn the original curated behavioral/transmission annotations from incomplete access.

The Falcon report completed and its principal fly genetics/localization synthesis agrees with the directly inspected 2009 source. However, it missed the 2010 Drosophila Imp13-Mago-Y14 structure and therefore overstates the absence of characterized fly cargoes. Its claim that cdm is merely an alias is also superseded by the current FlyBase symbol. Those limitations are recorded here; the provider text is preserved untouched. The YAML relies on the primary publications, rather than adding a redundant provider citation to suppress an advisory.

Both ProtNLM GO predictions are LSP: nucleocytoplasmic transport and intracellular protein transport are broader than supported specific protein nuclear import/export. Agreement with ARBA is not used as evidence, and overlap alone is not asserted to establish training-set contamination.