Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Human cytoplasmic serine hydroxymethyltransferase is an mRNA binding protein.
Heavy chain ferritin enhances serine hydroxymethyltransferase expression and de novo thymidine biosynthesis.
The role of serine hydroxymethyltransferase isozymes in one-carbon metabolism in MCF-7 cells as determined by (13)C NMR.
Carnitine biosynthesis in mammals.
Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway.
Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Distinct biochemical properties of human serine hydroxymethyltransferase compared with the Plasmodium enzyme: implications for selective inhibition.
A proteome-scale map of the human interactome network.
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.
IDH3α regulates one-carbon metabolism in glioblastoma.
Affinity purification and characterization of serine hydroxymethyltransferases from rat liver.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse.
Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1.
Purification and characterization of cytosolic and mitochondrial serine hydroxymethyltransferases from rat liver.
Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization.
The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy.
Metabolism of folate and pterines
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG
SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly