Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
PANTHER PTHR10868 PAINT annotations
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PTN001280219 is the fungal PAINT node that carries the C-8 sterol isomerase and ergosterol-biosynthesis assertions for PTHR10868.
"PTHR10868 PTN001280219 GO:0000247 F IBD false CGD:CAL0000177093|SGD:S000004815 taxon:451864 20251127"
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PTN001328958 is the broader eukaryotic PAINT node that propagates only ER localization, not the animal Sigma-receptor-specific terms, to fungal ERG2 proteins.
"PTHR10868 PTN001328958 GO:0005783 C IBD false MGI:MGI:1195268|RGD:68364|SGD:S000004815|UniProtKB:Q99720 taxon:2759 20260528"
UniProtKB record for N. crassa erg-1
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Neurospora erg-1 is annotated as a C-8 sterol isomerase acting in ergosterol biosynthesis.
"Steroid metabolism; ergosterol biosynthesis"
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UniProt annotates Neurospora erg-1 at the endoplasmic reticulum membrane by similarity.
"SUBCELLULAR LOCATION: Endoplasmic reticulum membrane"
Plasma Membrane Fusion Is Specifically Impacted by the Molecular Structure of Membrane Sterols During Vegetative Development of Neurospora crassa.
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Weichert et al. characterized N. crassa erg-1 as a sterol C-8 isomerase homologous to S. cerevisiae Erg2.
"erg-1 (NCU04156), which encodes a sterol C-8 isomerase homologous to Erg2 of S. cerevisiae"
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GC/MS analysis of the erg-1 deletion confirmed a block in ergosterol biosynthesis with accumulation of C-8/C-9 sterol intermediates.
"not only confirmed a block in ergosterol biosynthesis, but also the accumulation of mainly three sterol intermediates"