Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic Gene Ontology annotation based on Rhea mapping
Combined Automated Annotation using Multiple IEA Methods
Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans.
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NSY-1 functions downstream of Ca2+ signaling and CaMKII (UNC-43) in AWC asymmetry
"CaMKII activity acts as a switch in the initial decision to express str-2; thus, calcium signals can define distinct cell types during neuronal development"
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Calcium signals define distinct cell types during neuronal development
"calcium signals can define distinct cell types during neuronal development"
C. elegans odour discrimination requires asymmetric diversity in olfactory neurons.
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nsy-1 mutants (including ky542) have STR-2 expressed in both AWC neurons
"ky542 is an allele of nsy-1, a neuronal symmetry, or Nsy, mutant in which STR-2 is expressed in both AWC neurons"
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Nsy mutants exhibit chemotaxis and odor discrimination defects
"Other Nsy mutants exhibit discrimination and olfactory defects like those of nsy-1 mutants"
The CaMKII UNC-43 activates the MAPKKK NSY-1 to execute a lateral signaling decision required for asymmetric olfactory neuron fates.
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NSY-1 kinase activity demonstrated biochemically
"nsy-1 encodes a homolog of the human MAP kinase kinase kinase (MAPKKK) ASK1, an activator of JNK and p38 kinases"
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UNC-43/CaMKII activates NSY-1
"Based on genetic epistasis analysis, nsy-1 appears to act downstream of the CaMKII unc-43, and NSY-1 associates with UNC-43, suggesting that UNC-43/CaMKII activates the NSY-1 MAP kinase cassette"
SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans.
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NSY-1 is a MAP3K that phosphorylates SEK-1
"Genetic and biochemical analyses reveal that SEK-1 functions in a pathway downstream of UNC-43 and NSY-1, Ca2+/calmodulin-dependent protein kinase II (CaMKII) and MAPK kinase kinase (MAPKKK), respectively"
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NSY-1/SEK-1/MAPK cascade activated by Ca2+ signaling
"the NSY-1-SEK-1-MAPK cascade is activated by Ca2+ signaling through CaMKII and establishes asymmetric cell fate decision during neuronal development"
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Pathway establishes asymmetric cell fate in AWC neurons
"the NSY-1-SEK-1-MAPK cascade is activated by Ca2+ signaling through CaMKII and establishes asymmetric cell fate decision during neuronal development"
A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity.
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nsy-1 mutants are susceptible to P. aeruginosa and E. faecalis
"A genetic screen for Caenorhabditis elegans mutants with enhanced susceptibility to killing by Pseudomonas aeruginosa led to the identification of two genes required for pathogen resistance"
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NSY-1/SEK-1/PMK-1 constitute conserved p38 MAPK pathway for innate immunity
"RNA interference assays and biochemical analysis established that a p38 ortholog, pmk-1, functions as the downstream MAP kinase required for pathogen defense"
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Ancient feature of innate immune responses
"These data suggest that this MAP kinase signaling cassette represents an ancient feature of innate immune responses in evolutionarily diverse species"
Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins.
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p38 MAPK pathway defends against Cry5B pore-forming toxin
"A p38 mitogen-activated protein kinase (MAPK) kinase and a c-Jun N-terminal-like MAPK are both transcriptionally up-regulated by Cry5B"
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MAPK pathways are functionally important for toxin defense
"Moreover, both MAPK pathways are functionally important because elimination of either leads to animals that are (i) hypersensitive to a low, chronic dose of toxin and (ii) hypersensitive to a high, brief dose of toxin such that the animal might naturally encounter in the wild"
A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling.
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TIR-1 localizes NSY-1 to postsynaptic regions
"TIR-1 localizes NSY-1 to post-synaptic regions of AWC, and TIR-1 binds UNC-43, suggesting that it assembles a synaptic signaling complex that regulates odorant receptor expression"
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TIR-1 acts upstream of NSY-1 in asymmetry pathway
"Genetic evidence suggests that tir-1 acts downstream of a voltage-gated calcium channel and CaMKII (UNC-43) to regulate AWC asymmetry via the NSY-1(ASK1) p38/JNK MAP (mitogen-activated protein) kinase cascade"
Specificity and complexity of the Caenorhabditis elegans innate immune response.
Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade.
Stabilization of RNT-1 protein, runt-related transcription factor (RUNX) protein homolog of Caenorhabditis elegans, by oxidative stress through mitogen-activated protein kinase pathway.
The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression.
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NSY-1 is part of MAPK cassette for antimicrobial peptide induction
"We have shown that for nlp-29 cluster genes, following both infection and injury, inductive signaling passes via TPA-1, a protein kinase C delta (PKC∂) that acts upstream of TIR-1, the nematode ortholog of SARM, and a MAPK cassette comprising the MAP3K NSY-1, the MAP2K SEK-1, and PMK-1 [20]"
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Required for nlp-29 induction after D. coniospora infection
"We undertook a large-scale genetic screen for mutants that prevented the normal induction of a Pnlp-29::GFP reporter transgene after infection with D. coniospora"
A fasting-responsive signaling pathway that extends life span in C. elegans.
Deep research report on nsy-1