Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor.
Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis.
Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage.
Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway.
Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10.
CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system.
Protein kinase C theta is expressed in mast cells and is functionally involved in Fcepsilon receptor I signaling.
Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.
Vav2 is required for cell spreading.
Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis.
BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor.
Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation.
Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.
A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation.
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors.
Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells.
Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors.
The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity.
Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain.
Src-family kinases in B-cell development and signaling.
ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner.
Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling.
Structural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition motif that enhances binding affinity.
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome.
Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34+ marrow cells.
Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA).
Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis.
Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets.
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.
Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance.
Leupaxin negatively regulates B cell receptor signaling.
Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen.
Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts.
Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit.
Monocyte migration and LFA-1-mediated attachment to brain microvascular endothelia is regulated by SDF-1 alpha through Lyn kinase.
Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity.
Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.
Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain.
The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association.
SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.
DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.
Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals.
Lyn is involved in CD24-induced ERK1/2 activation in colorectal cancer.
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling.
Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers.
Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells.
Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway.
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis.
The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.
Interfering B cell receptor signaling via SHP-1/p-Lyn axis shows therapeutic potential in diffuse large B-cell lymphoma.
De Novo Gain-Of-Function Variations in LYN Associated With an Early-Onset Systemic Autoinflammatory Disorder.
Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome.
TLR9 signaling requires ligand-induced phosphorylation of two specific tyrosine residues by EGFR and Syk.
Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation.
G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase.Shc adapter protein signaling complexes.
Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling.
Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.
Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn.
Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22.
Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line.
Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.
Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation.
Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen
Fyn/Lyn-mediated phosphorylation of FcR1 gamma
Binding of Syk tyrosine kinase
GRB2 is indirectly recruited to p-KIT through SHP2
Phosphorylation of GAB2 by SFKs
Phosphorylation of SHP2 by SFKs
Synthesis of PIP3 from PIP2 by PI3K
Phosphorylation and activation of VAV1
Disassociation and translocation of STATs to the nucleus
Phosphorylation of p-KIT on Y900 by Src kinases
Indirect recruitment of PI3K to KIT via p(Y)-GAB2
Cell surface interactions at the vascular wall
Sequestering and phosphorylation Fc gamma receptors in the lipid rafts
Fcgamma receptor (FCGR) dependent phagocytosis
Indirect recruitment of GAB2 to p-KIT
SHP2 interacts with p-KIT
Recruitment of CBL to KIT
Interaction of APS and p-KIT
Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src
Fc epsilon receptor (FCERI) signaling
Phosphorylation of beta and gamma subunits by LYN
Recruitment of SYK to p-FCERI gamma subunit
Phosphorylation of TEC kinases by p-SYK
Phosphorylation of LAT by p-SYK
Phosphorylation of SLP-76 by p-SYK
Autophosphorylation of LYN kinase
Phosphorylation of PKC-theta
Phosphorylation of NTAL by p-SYK/Lyn
Phosphorylation of SHC by SYK kinase
SHP2 phosphatase binds CTLA-4
Phosphorylation of CTLA-4
Regulation of T cell activation by CD28 family
SFKs phosphorylate VAV2,3
EPHB phosphorylates TIAM1
VAV exchanges GTP for GDP on RAC1, activating it
TIAM1 exchanges GTP for GDP on RAC1, activating it
NGEF exchanges GTP for GDP on RHOA
p-TIAM1 exchanges GTP for GDP on RAC1, activating it
GPVI stimulates PI3K beta, gamma
LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG
C-type lectin receptors (CLRs)
SFKs phosphorylates RAF1 on Y340,Y341
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
EPOR-associated PI3K phosphorylates PIP2 to PIP3
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK
Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Phosphorylation of STATs downstream of KIT mutants
JAK2 binds to p-KIT mutants
Recruitment of STATs by KIT mutants
Dimerization of STATs downstream of KIT mutants
Phosphorylation of JAK2 downstream of KIT mutants
Disassociation and translocation of STATs to the nucleus downstream of KIT mutants
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN
CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
Growth hormone receptor signaling
Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated.
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Rat hepatocyte adherens-junction biochemistry identifies Lyn; microscopy emphasis on Src/Yes is not relabeled as Lyn imaging.
"As a result, three proto-oncogenic tyrosine kinases of src family, c-yes, c-src, and lyn kinases, were identified as major tyrosine kinases in the cell-to-cell AJ of hepatocytes."
Integrins direct Src family kinases to regulate distinct phases of oligodendrocyte development.
Rapid dephosphorylation of the GTPase dynamin after FcepsilonRI aggregation in a rat mast cell line.
Characterization and location of Src-dependent tyrosine phosphorylation in rat brain mitochondria.
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Rat mitochondrial Lyn immunogold signal lies in the cristal lumen; kinase localization is distinguished from membrane phosphoprotein substrates.
"Instead, Src tyrosine kinases are mainly located in the intermembrane space - in particular, as revealed by immunogold experiments for Lyn kinase, in the cristal lumen."
Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation.
Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia.
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Rat DRG co-IP supports a TRPV4/integrin/Lyn assembly, not Lyn as a structural chain of the alpha2-beta1 heterodimer.
"Furthermore, we establish a direct interaction between TRPV4, alpha2 integrin, and the Src tyrosine kinase Lyn in sensory neurons."
Protein tyrosine kinase p53/p56(lyn) forms complexes with gamma-tubulin in rat basophilic leukemia cells.
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Rat RBL cells and a recombinant Lyn N-terminal fragment support gamma-tubulin binding.
"Furthermore, gamma-tubulin bound to the N-terminal fragment of recombinant Lyn kinase and its binding was slightly enhanced in activated cells."
Src family tyrosine kinase p53/56lyn, a serine kinase and Fc epsilon RI associate with alpha-galactosyl derivatives of ganglioside GD1b in rat basophilic leukemia RBL-2H3 cells.
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Rat ganglioside-associated Lyn complexes are specific, but a protein bridge remains possible.
"The same 71-80-kDa tyrosine-phosphorylated proteins were immunoprecipitated by mAb AA4 and anti-Lyn antibodies and may play a role in the interaction of p53/56lyn with the gangliosides."
Inhibition of the B cell by CD22: a requirement for Lyn.
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Native mouse Lyn loss disrupts CD22 phosphorylation, SHP1 recruitment and suppression of BCR calcium signals; supports conserved human inhibitory signaling.
"We find that in the absence of Lyn, the ability of CD22 to become tyrosine phosphorylated after ligation of mIg, to recruit SHP-1, and to suppress mIg-induced elevation of intracellular [Ca2+] is lost."
Tyrosine phosphorylation-dependent and -independent associations of protein kinase C-delta with Src family kinases in the RBL-2H3 mast cell line: regulation of Src family kinase activity by protein kinase C-delta.
Interactions between Src family protein tyrosine kinases and PSD-95.
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Rat brain postsynaptic localization and recombinant PSD95–Lyn binding support a comparative neuronal pool.
"We find that Lck, Lyn, and Yes are localized to the postsynaptic density (PSD), the primary structural component of excitatory synapses."
LYN-deep-research-falcon.md
Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes.
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Cholesterol removal and restoration alter Lyn–FcεRI association and receptor phosphorylation in rat RBL cells.
"Importantly, cholesterol repletion restores receptor phosphorylation together with the structural interactions."
Fosinopril and carvedilol reverse hypertrophy and change the levels of protein kinase C epsilon and components of its signaling complex.
L-DOPA treatment of parkinsonian rats changes the expression of Src, Lyn and PKC kinases.
Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2.
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Insulin, unlike leptin, increases Lyn autophosphorylation in perfused rat liver.
"Insulin alone (P < 0.01), but not leptin, increased autophosphorylation of nonreceptor tyrosine kinases (pp59(Lyn) + pp125(Fak))."
Lyn- and ERK-mediated vs. Ca2+ -mediated neutrophil O responses with thermal injury.
The Src family kinase, Lyn, is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters and growth factors which stimulate its association with numerous other signaling molecules.
Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury.
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Native mouse Lyn deficiency impairs injury-induced microglial signaling and tactile allodynia.
"We found that mice lacking lyn (lyn(-/-)) exhibit a striking reduction in the levels of phospho-SFK-IR and tactile allodynia after nerve injury, without any change in basal mechanical sensitivity or inflammatory pain."