UniProtKB record for human CD86 (P42081)
Falcon deep research report for human CD86
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Expression of costimulatory molecules CD80 and CD86 and their receptors CD28, CTLA-4 on malignant ascites CD3+ tumour-infiltrating lymphocytes (TIL) from patients with ovarian and other types of peritoneal carcinomatosis.
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.
The interaction properties of costimulatory molecules revisited.
Exosomal-like vesicles are present in human blood plasma.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
A secreted protein microarray platform for extracellular protein interaction discovery.
Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines.
CD80 and CD86 IgC domains are important for quaternary structure, receptor binding and co-signaling function.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions.
Human and viral membrane-associated E3 ubiquitin ligases MARCH1 and MIR2 recognize different features of CD86 to downregulate surface expression.
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Human MARCH1 recognises a specific surface in the CD86 transmembrane domain (featuring Pro254) to ubiquitinate and downregulate CD86.
"We identified a highly specific recognition surface in the hydrophobic core of the CD86 transmembrane (TM) domain (TMD) that is required for recognition by MARCH1 and prominently features a proline at position 254."
A physical wiring diagram for the human immune system.
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation.
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CTLA4 removes CD86 from APCs by transendocytosis and then recycles, making CD86 a key target of CTLA4 regulation.
"in the presence of CD86, CTLA-4 detached in a pH-dependent manner and recycled back to the cell surface to permit further transendocytosis."
Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule.
CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.
Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation.
CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28.
PI3K phosphorylates PIP2 to PIP3
PI3K inhibitors block PI3K catalytic activity
CD28 homodimer binds B7-2 monomer
SHP2 phosphatase binds CTLA-4
Phosphorylation of CTLA-4
CD28 bound PI3K phosphorylates PIP2 to PIP3
Activation of Rac1 by pVav1
Activation of Cdc42 by pVav1
Translocation of Vav1 to CD28
IL10 negatively regulates plasma membrane-associated inflammatory mediators