Lamin B receptor recognizes specific modifications of histone H4 in heterochromatin formation.
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The LBR Tudor domain preferentially binds H4K20me2 and recruits epigenetically marked chromatin to the nuclear envelope; the whole nucleoplasmic domain is needed for transcriptional repression beneath the NE.
"the tudor domain of LBR primarily recognizes histone H4 lysine 20 dimethylation (H4K20me2) to recruit epigenetically marked chromatin to the NE."
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3 beta-hydroxysterol delta 14-reductase deficiency due to mutations in the lamin B receptor gene.
Increased susceptibility of glutathione peroxidase-1 transgenic mice to kainic acid-related seizure activity and hippocampal neuronal cell death.
The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain.
Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis.
Defining the membrane proteome of NK cells.
Mutations causing Greenberg dysplasia but not Pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929.
The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations.
Architecture of the human interactome defines protein communities and disease networks.
C1QBP is upregulated in colon cancer and binds to apolipoprotein A-I.
A reference map of the human binary protein interactome.
TMEM147 interacts with lamin B receptor, regulates its localization and levels, and affects cholesterol homeostasis.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane.
Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1.
Human lamin B receptor exhibits sterol C14-reductase activity in Saccharomyces cerevisiae.
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]
Cholesterol biosynthesis via desmosterol (Bloch pathway)
Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing.
Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huët anomaly).
Inner nuclear membrane protein LBR preferentially interacts with DNA secondary structures and nucleosomal linker.
UniProtKB entry Q14739 (LBR_HUMAN), Delta(14)-sterol reductase LBR