pax6b notes (DANRE, A0A0R4IQL7)

2026-09-27 session log

• Deep research FAILED for this gene (Edison: 402 Payment Required; OpenAI key invalid). Not retried.
  Literature research done manually (Europe PMC REST); see pax6a-notes.md for the searches and new PMIDs.

Key facts with provenance

• Naming: pax6b = old pax6.2 (Nornes 1998 "Pax6.2")
  PMID:18282108
• sunrise = pax6b L244P homeodomain missense; homozygous viable
  PMID:18282108
• Null allele sa0086 (Y109*): PMID:20177065
• Pancreas: only pax6b expressed PMID:18282108
• Endocrine phenotype: PMID:20177065
• Homeodomain needed for lens, not pancreas: PMID:20177065
• Enteroendocrine: PMID:32867764
• Cornea: PMID:25692557
• Habenula NOT pax6b: PMID:27387288
• Regeneration: PMID:20152834

Decisions

• All 59 GOA rows reviewed; the experimental IMP/IGI/IDA rows are accepted (non-core for A/P patterning,
  hindbrain, epithalamus, regulation of gene expression, neural crest migration, cell differentiation).
• Epithalamus IGI kept as non-core: evidence is double knockdown; later work shows the habenula role is pax6a's.
• MODIFY IEA GO:0006351 DNA-templated transcription -> GO:0006357.
• NEW GO:2000179 (IMP PMID:20152834), mirroring the (modified) pax6a annotation from the same paper.