slc7a10a notes

Setup and provenance

• Fetched with just fetch-gene on G8JL19 (TrEMBL, 511 aa); 10 GOA rows (5 IBA, 5 IEA), none with a PMID. ZFIN
  ZDB-GENE-080116-1, Ensembl ENSDARG00000008100, chromosome 7.
• Deep research unavailable: Edison returned 402 Payment Required and the OpenAI key is invalid. Literature
  searched by hand via Europe PMC ((slc7a10b OR slc7a10a), (slc7a10 OR slc7a10a OR slc7a10b OR asc-1) AND zebrafish, slc7a10 AND (fish OR teleost), Asc-1 structure/knockout queries).
• DANRE_DUPLICATION batch 4, random draw 18 (seed 20260928); paralog slc7a10b. PANTHER TGD_tree 1:1 pair (PTHR11785);
  Ensembl Compara places the duplication at Osteoglossocephalai.

Zebrafish literature

• No functional study of slc7a10a. A catalogue of zebrafish SLC7 genes lists an adult EST profile for slc7a10a only
  PMID:34338990.
• The zebrafish obesity study used slc7a10b, chosen by sequence identity
  PMID:36172277.

Mammalian SLC7A10 (Asc-1)

• Na-independent small neutral amino acid exchanger that needs 4F2hc
  PMID:10734121;
  PMID:10734121;
  also D-serine PMID:10734121.
• Structure: disulfide to 4F2hc PMID:38589439;
  gate residues PMID:38589439.
• In vivo: glycine supply for inhibitory transmission
  PMID:25755256;
  astrocytic in caudal CNS PMID:27759100.

My analysis (slc7a10a-bioinformatics/RESULTS.md)

• 77.8% identity between copies; both closer to SLC7A10 than to SLC7A8. All ten tested Asc-1 residues (N52, Y131,
  I138, C154, F243, F250, Y253, E257, Y333, R339) conserved in both copies, gar, coelacanth and medaka.
• slc7a10a evolves somewhat faster (42 vs 25 unique changes vs gar; P<0.05).
• Expression: slc7a10a broad (21 Bgee calls including heart, kidney, muscle, intestine, bone, brain) and rising in
  larvae; slc7a10b narrow (brain, eye, bone, testis, early embryo). Gar SLC7A10 calls resemble slc7a10b.

GOA review decisions

All 10 rows accepted (IBA rows at the right level; IEA rows general but correct).