Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic Gene Ontology annotation based on Rhea mapping

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells.

TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis.

Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.

Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38).

Expression of the Bcl-2 protein BAD promotes prostate cancer growth.

CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.

Toward an understanding of the protein interaction network of the human liver.

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.

Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets.

Architecture of the human interactome defines protein communities and disease networks.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

OpenCell: Endogenous tagging for the cartography of human cellular organization.

A central chaperone-like role for 14-3-3 proteins in human cells.

Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase.

PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway.

MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway.

Structural basis for MEKK2 dimerization and substrate recognition.

Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells.

Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction.

MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation.

MEKK2 and MEKK3 orchestrate multiple signals to regulate Hippo pathway.

Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation.

UniProt record for human MAP3K2 (Q9Y2U5)

Falcon deep research report for human MAP3K2

MEKK2 kinase association with 14-3-3 protein regulates activation of c-Jun N-terminal kinase.

14-3-3 proteins interact with specific MEK kinases.

Phosphorylation of MEKK3 at threonine 294 promotes 14-3-3 association to inhibit nuclear factor kappaB activation.

Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation.