Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis.
The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease.
HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases.
Structural basis for the inhibition of caspase-3 by XIAP.
Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death.
Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts.
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease.
Caspase 3 activation is controlled by a sequence located in the N-terminus of its large subunit.
S-nitrosation of thioredoxin in the nitrogen monoxide/superoxide system activates apoptosis signal-regulating kinase 1.
A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53.
A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association.
Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis.
Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway.
N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system.
Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death.
Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1.
Caspase-3-mediated cleavage of Akt: involvement of non-consensus sites and influence of phosphorylation.
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity.
The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery.
Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells.
Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3.
No death without life: vital functions of apoptotic effectors.
Executioner caspase-3 and caspase-7 are functionally distinct proteases.
Huntingtin promotes cell survival by preventing Pak2 cleavage.
S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease.
Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis.
A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function.
Identification of functional regions defining different activity in caspase-3 and caspase-7 within cells.
Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.
Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway.
Toward an understanding of the protein interaction network of the human liver.
Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease.
Regulation of co- and post-translational myristoylation of proteins during apoptosis: interplay of N-myristoyltransferases and caspases.
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation.
The human papillomavirus-16 E7 oncoprotein exerts antiapoptotic effects via its physical interaction with the actin-binding protein gelsolin.
Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis.
Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.
Architecture of the human interactome defines protein communities and disease networks.
Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane.
Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia.
Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells.
Apoptotic caspase inhibits innate immune signaling by cleaving NF-κBs in both Mammals and Flies.
TRIM21 Regulates Virus-Induced Cell Pyroptosis through Polyubiquitination of ISG12a.
Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine.
Mapping adipocyte interactome networks by HaloTag-enrichment-mass spectrometry.
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis.
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c.
Casper is a FADD- and caspase-related inducer of apoptosis.
Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells.
Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage.
Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis.
Cleavage of Procaspase-3 by the apoptosome
Caspase-mediated cleavage of plakophilin-1
Caspase-mediated cleavage of PKC theta
Caspase-mediated cleavage of alpha adducin
Caspase-mediated cleavage of Rock-1
Caspase-mediated cleavage of gelsolin
Caspase-mediated cleavage of vimentin at DSVD (85)
Caspase-mediated cleavage of Tau
Caspase-mediated cleavage of Acinus
Caspase-mediated cleavage of Desmoglein 3
Caspase-mediated cleavage of Desmoplakin
Caspase-mediated cleavage of GAS2
Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha
Cleavage of p-STK4 (p-MST1) by caspase 3
Cleavage of p-STK3 (p-MST2) by caspase 3
Caspase-mediated cleavage of Desmoglein 1
Caspase-mediated cleavage of E-Cadherin
Caspase mediated cleavage of APC
Caspase mediated cleavage of C-IAP1
Caspase mediated cleavage of HIP-55
Caspase mediated cleavage of alpha-II-Fodrin
Caspase mediated cleavage of beta-catenin
p75NTR:NADE promotes caspase2/3 activation
Cleavage of DFF45 (224) by caspase-3
Caspase 3-mediated cleavage of DFF45 (117)
Translocation of caspase-3 to the nucleus
Caspase 3-mediated cleavage of PKC delta
Caspase-mediated cleavage of MASK
Caspase-mediated cleavage of Etk
Caspase-mediated cleavage of Z0-2
Caspase-mediated cleavage of occludin
Caspase-mediated cleavage of Desmoglein 2
Caspase-mediated cleavage of MST3
Caspase-mediated cleavage of TJP1
Caspase-3 cleaves pro-interleukin-16
Falcon deep research report for CASP3
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Falcon corroborates the review's core characterization of CASP3 as the principal executioner caspase and a cysteine protease that cleaves strictly after aspartate at the P1 position.
"Caspase-3 is a cysteine protease that cleaves peptide bonds almost exclusively C-terminal to aspartate residues at the P1 position"