Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Molecular biology of channel catfish gonadotropin receptors: 1. Cloning of a functional luteinizing hormone receptor and preovulatory induction of gene expression.
Three-dimensional structure of human follicle-stimulating hormone.
Structure of human follicle-stimulating hormone in complex with its receptor.
-
Crystal structure of human FSH (CGA:FSHB) bound to the extracellular hormone-binding domain of FSHR.
"We present here the 2.9-A-resolution structure of a partially deglycosylated complex of human FSH bound to the extracellular hormone-binding domain of its receptor (FSHR(HB))."
Follicular stimulating hormone enhances Notch 1 expression in SK-OV-3 ovarian cancer cells.
Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor.
-
All four human glycoprotein hormones (FSH, LH, TSH, and hCG) are heterodimers of the common alpha subunit CGA and a hormone-specific beta subunit.
"Each member is a heterodimer composed of a common α-subunit and a hormone-specific β-subunit."
Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer.
Expression of biologically active human follitropin in Chinese hamster ovary cells.
A review of luteinising hormone and human chorionic gonadotropin when used in assisted reproductive technology.
GPCR Signaling and Trafficking: The Long and Short of It.
The forgotten effects of thyrotropin-releasing hormone: Metabolic functions and medical applications.
Maximizing binary interactome mapping with a minimal number of assays.
Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells.
Novel TSHB variant (c.217A>C) causing severe central hypothyroidism and pituitary hyperplasia.
-
TSH, LH, FSH, and hCG are heterodimers of the common alpha subunit (CGA) and a subtype-specific beta subunit.
"TSH is a member of the glycoprotein hormone family, which includes luteinising hormone, follicle-stimulating hormone, and human chorionic gonadotropin. All are heterodimers of a common α subunit and subtype-specific β subunit, which determines the biologic specificity."
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor.
-
FSH, LH, CG, and TSH share conserved heterodimeric 3D architectures and signal by binding and activating the glycoprotein hormone GPCR subfamily.
"FSH, along with luteinizing hormone (LH), chorionic gonadotropin (CG) and thyroid-stimulating hormone (TSH), constitute the family of glycoprotein hormones14, which share similar 3D architectures and function through binding and activation of a subfamily of G protein-coupled receptors, named glycoprotein hormone receptors15."
Structure of human chorionic gonadotropin at 2.6 A resolution from MAD analysis of the selenomethionyl protein.
Thyrotropin is a heterodimer
Luteinizing hormone is a heterodimer
Follitropin is a heterodimer
CGA and CGB3 bind to form Human chorionic gonadotropin (hCG)
Liganded Gs-activating GPCR acts as a GEF for Gs
TSHR binds TSH/Thyrostimulin
Luteinizing hormone receptor can bind LH
Follicle-stimulating hormone receptor can bind FSH
CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin
The Ligand:GPCR:Gs complex dissociates
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
TFAP2A,TFAP2C homodimers stimulate CGA gene expression
Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets.