Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Combined Automated Annotation using Multiple IEA Methods

Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism.

Defining the membrane proteome of NK cells.

Purification and interaction analyses of two human lysosomal vitamin B12 transporters: LMBD1 and ABCD4.

Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1.

Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B(12)-trafficking proteins ABCD4 and LMBD1.

The lysosomal protein ABCD4 can transport vitamin B(12) across liposomal membranes in vitro.

ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells)

Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol

ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol

UniProtKB entry Q9NUN5 (LMBD1_HUMAN)