Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function.
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Stress and mTORture signaling.
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
Identification of Protor as a novel Rictor-binding component of mTOR complex-2.
P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration.
Integral and associated lysosomal membrane proteins.
cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner.
Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.
eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy.
AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation.
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.
Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.
Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities.
The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway.
Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells.
Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission.
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1.
Network organization of the human autophagy system.
Activation of a metabolic gene regulatory network downstream of mTOR complex 1.
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.
Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis.
Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1.
Probing cellular protein complexes using single-molecule pull-down.
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.
5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.
Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells.
PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription.
mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity.
Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis.
Rab1A is an mTORC1 activator and a colorectal oncogene.
The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR.
Huntingtin functions as a scaffold for selective macroautophagy.
mLST8 Promotes mTOR-Mediated Tumor Progression.
La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1).
GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling.
NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.
Architecture of human mTOR complex 1.
The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity.
HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth.
4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1.
mTOR Signaling in Growth, Metabolism, and Disease.
Architecture of the human interactome defines protein communities and disease networks.
Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A.
The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling.
GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.
Structural basis for the docking of mTORC1 on the lysosomal surface.
Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Leucine regulates autophagy via acetylation of the mTORC1 component raptor.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
SNAT7 regulates mTORC1 via macropinocytosis.
Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor.
O-GlcNAcylation of Raptor transduces glucose signals to mTORC1.
Formation of active mTORC1 complex
Phosphorylation of 4E-BP1 by activated mTORC1
mTORC1 phosphorylation of RPS6KB1 (S6K)
Activated Akt1 phosphorylates AKT1S1 (PRAS40)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP
AMPK phosphorylates Raptor in the mTORC1 complex
Phosphorylation of HSF1 at Ser326 induces transactivation
Ragulator:Rag dimers:SLC38A9 bind mTORC1
Active MTORC1 phosphorylates ULK1
Rheb in the MTORC1 complex hydrolyses GTP
Active MTORC1 binds the ULK1 complex
mTORC1 phosphorylates AKT1S1
AKT1S1 (PRAS40) binds mTORC1
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
MTORC1 dissociates from ULK complex
mTORC1 phosphorylates MAF1
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1