Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients.

Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L.

Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter.

NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state.

A proteome-scale map of the human interactome network.

Identification of EFHD1 as a novel Ca(2+) sensor for mitoflash activation.

The mitochondrial inner membrane protein LETM1 modulates cristae organization through its LETM domain.

A reference map of the human binary protein interactome.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Bi-allelic LETM1 variants perturb mitochondrial ion homeostasis leading to a clinical spectrum with predominant nervous system involvement.

TMBIM5 is the Ca(2+) /H(+) antiporter of mammalian mitochondria.

The solute carrier superfamily interactome.

Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1.