Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

PUMA induces the rapid apoptosis of colorectal cancer cells.

PUMA, a novel proapoptotic gene, is induced by p53.

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals.

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53.

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53.

PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells.

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.

Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways.

DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH.

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity.

The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity.

Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.

BH3 domains other than Bim and Bid can directly activate Bax/Bak.

The unfolded protein response: integrating stress signals through the stress sensor IRE1α.

Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency.

CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress.

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.

Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt's lymphoma B cells.

Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine.

Architecture of the human interactome defines protein communities and disease networks.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Multimodal cell maps as a foundation for structural and functional genomics.

TP53 stimulates BBC3 (PUMA) expression

Translocation of BBC3 (PUMA) protein to mitochondria

Transactivation of BBC3 (PUMA) by E2F1

BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2

BBC3 gene expression is stimulated by FOXO3,(FOXO1)

Manual BBC3 curation notes

BBC3 UniProtKB record Q9BXH1