GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

PMID:22125637

The entomopathogenic bacterial endosymbionts Xenorhabdus and Photorhabdus: convergent lifestyles from divergent genomes

This is the genome sequencing paper for Xenorhabdus nematophila strain ATCC 19061, the source of the XNC1_0570 (D3VIU4) gene model.

PMID:15262924

Three different systems participate in L-cystine uptake in Bacillus subtilis.

The B. subtilis TcyABC (YckKJI) ABC system, whose binding protein TcyA is in the same PANTHER subfamily (SF34) as D3VIU4, contributes to L-cystine uptake.

PMID:22138345

Crystal structures of two solute receptors for L-cystine and L-cysteine, respectively, of the human pathogen Neisseria gonorrhoeae.

Ngo0372 binds L-cystine with nanomolar affinity; Tyr59 in its pocket is crucial for binding. The equivalent tyrosine and tryptophan are conserved in D3VIU4.

PMID:26350134

Physiological Roles and Adverse Effects of the Two Cystine Importers of Escherichia coli.

E. coli FliY (TcyJ) is a periplasmic cystine-binding protein of the high-affinity FliY-YecSC importer. E. coli TcyJ is in PANTHER SF35, a different subfamily from D3VIU4, so its kinetic properties are not transferred.

file:XENNA/D3VIU4/D3VIU4-deep-research-falcon.md

Deep research report on D3VIU4 fliY from Xenorhabdus nematophila

The report treats D3VIU4 as the ortholog of E. coli FliY/TcyJ and transfers E. coli kinetics. Subfamily placement does not support that orthology (D3VIU4 is SF34, E. coli TcyJ SF35).

file:XENNA/D3VIU4/D3VIU4-bioinformatics/RESULTS-rereview.md

D3VIU4 re-review: placement among family-3 cystine-binding proteins

D3VIU4 is in SF34 with TcyA, is 48% identical to TcyA and Ngo0372 versus 39% to E. coli TcyJ, conserves the Ngo0372 pocket Tyr/Trp, and sits in a conserved SBP-ATPase-permease cluster.