"several cDNA clones were isolated that encode a secreted form of the human IL-7 receptor capable of binding IL-7 in solution"

"the gamma chain participates in the functional high-affinity receptor complexes for IL-7"

"involved in the differentiation of T and B cells"

"IL-2R gamma was shown to be physically associated with the IL-7 receptor. The presence of IL-2R gamma augmented both IL-7 binding affinity and the efficiency of internalization of IL-7."

"this process is regulated by the alpha-chain of the receptor for interleukin-7, a cytokine that stimulates B-cell lymphopoiesis"

"defective IL7R expression causes T(-)B(+)NK(+) SCID"

"the T-cell, but not the NK-cell, defect in XSCID results from inactivation of IL-7Ralpha signalling"

"Human TSLP is proposed to signal through a heterodimeric receptor complex that consists of a new member of the hemopoietin family termed human TSLP receptor and the IL-7R alpha-chain. Cells transfected with both receptor subunits proliferated in response to purified, recombinant human TSLP, with induced phosphorylation of Stat3 and Stat5."

"IL-7 and IL-7Ralpha bind the gamma(c) receptor, forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells"

"IL-7 binds glycosylated IL-7Ralpha 300-fold more tightly than unglycosylated IL-7Ralpha, and the enhanced affinity is attributed primarily to an accelerated on rate"

"Structural comparison of IL-7 in complex to both forms of IL-7Ralpha reveals that glycosylation does not participate directly in the binding interface"

"TSLP signals via IL-7Ralpha and a specific TSLPR subunit that is highly related to the common cytokine receptor gamma chain"

"We now demonstrate the role of JAK1 and JAK2 in TSLP-mediated STAT5 phosphorylation in mouse and human primary CD4(+) T cells, in contrast to the known activation of JAK1 and JAK3 by the related cytokine, IL-7"

"just as JAK1 interacts with IL-7Ralpha, JAK2 is associated with TSLPR protein"

"we demonstrate the importance of STAT5 activation for TSLP-mediated survival and proliferation of CD4(+) T cells"

"The dataset, versioned HI-III-20 (Human Interactome obtained from screening Space III, published in 2020), contains 52,569 verified PPIs involving 8,275 proteins"

"HuRI substantially expands the number of biomedically interesting genes for which high-quality direct PPI data is available"

"we came to the surprising conclusion that IL-7, not IL-15, is the homeostatic cytokine for iNKT cells"

"The coupling of highly sensitive BRET biosensors with miniaturized coexpression in an ultra-HTS format allows large-scale monitoring of the interactions of wild-type and mutant variant counterparts with a library of cancer-associated proteins in live cells"

"The screening of 17,792 interactions with 2,172,864 data points revealed a landscape of gain of interactions encompassing both oncogenic and tumor suppressor mutations"

"MARCH8 mediates K27-linked polyubiquitination of IL-7Ralpha, leading to its lysosomal degradation"

"MARCH8 negatively regulates IL-7-triggered signaling by mediating K27-linked polyubiquitination and lysosomal degradation of IL-7Ralpha"

"Coimmunoprecipitation and proximity ligation studies demonstrate physical interaction between CD53 and IL-7R"

"Cd53-/- mice have reduced surface expression of IL-7Ralpha"