GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000108
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:12189247
A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors.
PMID:14623738
A Korean kindred with autosomal dominant nocturnal frontal lobe epilepsy and mental retardation.
PMID:16238698
The cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits.
PMID:16332175
Polymorphisms of the CHRNA4 gene encoding the alpha4 subunit of nicotinic acetylcholine receptor as related to the oxidative DNA damage and the level of apoptotic proteins in lymphocytes of the patients with Alzheimer's disease.
PMID:17132685
Ca2+ permeability of the (alpha4)3(beta2)2 stoichiometry greatly exceeds that of (alpha4)2(beta2)3 human acetylcholine receptors.
PMID:17613539
Association of attentional network function with exon 5 variations of the CHRNA4 gene.
PMID:17955458
Gene-environment interactions in the development of combined type ADHD: evidence for a synapse-based model.
PMID:20438829
Low ethanol concentration alters CHRNA5 RNA levels during early human development.
PMID:20881005
Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function.
PMID:27344019
Functional interaction between Lypd6 and nicotinic acetylcholine receptors.
PMID:27698419
X-ray structure of the human α4β2 nicotinic receptor.
PMID:29720657
Structural principles of distinct assemblies of the human α4β2 nicotinic receptor.
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
PMID:38454578
Structural bases for stoichiometry-selective calcium potentiation of a neuronal nicotinic receptor.
PMID:7550350
A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy.
PMID:8906617
Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.
Reactome:R-HSA-622325
Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors
Reactome:R-HSA-622326
Activation of highly calcium permeable nicotinic acetylcholine receptors
Reactome:R-HSA-629588
Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors
Reactome:R-HSA-629595
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Reactome:R-HSA-629596
Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Reactome:R-HSA-629599
Binding of acetylcholine to highly calcium permeable acetylcholine receptors
PMID:10235262
Reduced antinociception in mice lacking neuronal nicotinic receptor subunits.
PMID:15963492
Nicotinic receptors regulate B lymphocyte activation and immune response.
PMID:12944511
Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice.
PMID:17146052
Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy.
PMID:22593584
A highly conserved cytoplasmic cysteine residue in the α4 nicotinic acetylcholine receptor is palmitoylated and regulates protein expression.
PMID:42149943
Cardiac α4β2 nicotinic receptors as a therapeutic target for fatal ventricular arrhythmias.
file:human/CHRNA4/CHRNA4-source-evidence.json
CHRNA4 source records and review provenance