Gene Ontology annotation through association of InterPro records with GO terms.
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Combined Automated Annotation using Multiple IEA Methods.
Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.
Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II.
Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin-dependent protein kinase II.
Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.
Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling.
PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation.
Deep Research Report on CAMK2A
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Automatic Gene Ontology annotation based on Rhea mapping.
Electronic Gene Ontology annotations created by ARBA machine learning models
Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II.
Proteomic characterization of the human sperm nucleus.
A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme.
De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A central chaperone-like role for 14-3-3 proteins in human cells.
Trafficking of GluR1-containing AMPA receptors
Ca2+ influx into the post-synaptic cell
Dissociation of CaM and CAMK2 autophosphorylation
Active calmodulin binds CAMK2
Autophosphorylation and activation of CAMK2
Activation of MAP3K7 in response to WNT
Phosphorylation of HSF1 at Ser230 induces transactivation
RAS GEFs promote RAS nucleotide exchange
Phosphorylation of STAT1 at Ser727
CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling.
CaMKII determines mitochondrial stress responses in heart.
Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle.
Essential function of alpha-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse.
Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses.
CaMKII binding to GluN2B is critical during memory consolidation.
Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII.
Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2.
NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.
UniProtKB Q9UQM7 (KCC2A_HUMAN)