Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Combined Automated Annotation using Multiple IEA Methods
Phosphoserine aminotransferase, the second step-catalyzing enzyme for serine biosynthesis.
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Characterizes the mammalian (bovine liver) phosphoserine aminotransferase as the second-step enzyme of serine biosynthesis, with kinetic parameters for 3-phosphohydroxypyruvate, phosphoserine, glutamate, and alpha-ketoglutarate.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
L-serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase.
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Full functional and structural characterization of recombinant human PSAT; PLP-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine and alpha-ketoglutarate, homodimer with cofactor at the monomer-monomer interface, apo and OPS-bound crystal structures.
Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization.
PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation.
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PSAT1 phosphoserine aminotransferase activity is abolished by the K200A active-site mutation; separately, IFN-gamma/CAMK2A-driven phosphorylation at Ser337 lets PSAT1 bind and stabilize GPX4 (via alpha-ketoglutarate-dependent PHD3 hydroxylation), suppressing ferroptosis.
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA