Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
UniProtKB entry P31939 (ATIC / PUR9_HUMAN)
Human AICAR transformylase: role of the 4-carboxamide of AICAR in binding and catalysis.
The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling.
Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor.
Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase.
Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Defining the membrane proteome of NK cells.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Colocalization and Sequential Enzyme Activity in Aqueous Biphasic Systems: Experiments and Modeling.
The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping.
Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase.
AICAR + 10-Formyl-THF => FAICAR + THF
Ligand-independent dimerization of ALK fusions
Autophosphorylation of ALK fusions
ALK mutants phosphorylate SHC1
ALK fusion proteins bind PLCG1
ALK fusions phosphorylate PLCG1
ALK mutants:p-3Y SHC binds GRB2