Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
PtxR modulates the expression of QS-controlled virulence factors in the Pseudomonas aeruginosa strain PAO1.
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ptxR mutation increases pyocyanin production.
"Mutation of ptxR in PAO1 increased pyocyanin production."
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ptxR mutation decreases lasB expression.
"ptxR mutation increased the expression of the rhamnolipid synthesis gene rhlA but decreased lasB expression"
Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS.
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PtxR binds a palindromic operator in the toxA promoter.
"PtxR binds to the toxA promoter, and that the operator site corresponds to a short palindrome"
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toxA expression is three-fold lower in a ptxR deletion.
"In this study we confirmed that in a ΔptxR background, expression of toxA is almost three-fold lower than in the parental strain, an observation which confirms the positive role of PtxR."
Isolation and characterization of a Pseudomonas aeruginosa gene, ptxR, which positively regulates exotoxin A production.
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PtxR is a LysR-family homolog that increases toxA and regA transcription.
"ptxR increases toxA and regA transcription"
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The measured activity reduced in ptxR mutants is exotoxin A activity.
"both mutants showed a significant reduction in the level of exotoxin A activity"