UniProtKB entry for PP_2634
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UniProt carries the generic submitted name "Cellulose synthase" for PP_2634, but its InterPro/Pfam/NCBIfam cross-references identify a BcsQ/YhjQ-family P-loop NTPase.
"DR InterPro; IPR017746; Cellulose_synthase_operon_BcsQ."
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PP_2634 has P-loop NTPase-family signatures and no BcsA-like GT2 cellulose synthase catalytic annotation.
"DR InterPro; IPR027417; P-loop_NTPase."
BcsQ is an essential component of the Escherichia coli cellulose biosynthesis apparatus that localizes at the bacterial cell pole.
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The primary BcsQ paper shows that yhjQ/BcsQ is essential for cellulose biosynthesis and polar localization in the enterobacterial reference system.
"we show that yhjQ, but not yhjR, is essential for cellulose biosynthesis; it has therefore been renamed bcsQ"
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The same paper identifies BcsQ as a MinD homolog with polar localization.
"we demonstrate that BcsQ, a MinD homologue, displays a polar localization"
Architecture and regulation of an enterobacterial cellulose secretion system.
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E. coli BcsRQ forms ATP-bound sandwich dimers; wild-type hydrolysis is weak and inhibited by BcsE. The coupling of hydrolysis to downstream cellulose secretion is a mechanistic model, not demonstrated KT2440 ATPase activity.
"the BcsHisRQWT complex exhibited only weak adenosine triphosphatase (ATPase) activity in vitro"
Structural basis for synthase activation and cellulose modification in the E. coli Type II Bcs secretion system.
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The E. coli macrocomplex directly places BcsQ against BcsA PilZ, providing structural participation evidence beyond a deletion phenotype.
"BcsQ buttresses the PilZ domain, likely stabilizing the catalytically competent state."
Transcriptional organization, regulation and functional analysis of flhF and fleN in Pseudomonas putida.
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P. putida-specific work shows c-di-GMP/FleQ/FleN regulation of the bcs promoter, placing PP_2634's operon in the biofilm regulatory program.
"PbcsD was negatively regulated by FleQ and FleN, and repression was antagonized by c-di-GMP"
Cell-cell and cell-surface interactions mediated by cellulose and a novel exopolysaccharide contribute to Pseudomonas putida biofilm formation and fitness under water-limiting conditions.
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The abstract explicitly studies P. putida mt2. It reports a minor bcs contribution to biofilm stability and a contribution to rhizosphere colonization; these are operon-level phenotypes, not KT2440 target-protein assays.
"The composition of the exopolysaccharide matrix of Pseudomonas putida mt2"
OpenScientist gene research for PP_2634
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OpenScientist identifies PP_2634/Q88JL5 as BcsQ, a MinD/ParA-family P-loop ATPase accessory factor, and flags the "Cellulose synthase" submitted name as a mis-annotation.
"PP_2634 is **BcsQ**, an accessory **MinD/ParA-family P-loop ATPase**"