Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
GOA annotation export for MBL2
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GOA records the phylogenetic IBA source for the MBL2 GO:0043129 annotation.
"UniProtKB P11226 MBL2 involved_in GO:0043129 surfactant homeostasis biological_process ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN001523874|RGD:3667|UniProtKB:P35247 9606 Homo sapiens GO_Central Mannose-binding protein C 20170613"
OpenScientist hypothesis report for MBL2 GO:0043129
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OpenScientist refutes surfactant homeostasis as a direct MBL2 function.
"The seed hypothesis that **MBL2 has surfactant homeostasis (GO:0043129)** is **over-annotated / refuted as a direct function.**"
Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL.
MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway.
Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1.
Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2.
High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene.
The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin.
Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus.
The chaperone and potential mannan-binding lectin (MBL) co-receptor calreticulin interacts with MBL through the binding site for MBL-associated serine proteases.
Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins.
MBL-associated serine protease-3 circulates in high serum concentrations predominantly in complex with Ficolin-3 and regulates Ficolin-3 mediated complement activation.
Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity.
Serum concentration and interaction properties of MBL/ficolin associated protein-1.
CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site.
Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system.
Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry.
Serglycin inhibits the classical and lectin pathways of complement via its glycosaminoglycan chains: implications for multiple myeloma.
Mannan-binding lectin directly interacts with Toll-like receptor 4 and suppresses lipopolysaccharide-induced inflammatory cytokine secretion from THP-1 cells.
MASP interactions with plasma-derived MBL.
Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2.
The salivary scavenger and agglutinin binds MBL and regulates the lectin pathway of complement in solution and on surfaces.
Crystal structure and functional characterization of the complement regulator mannose-binding lectin (MBL)/ficolin-associated protein-1 (MAP-1).
Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function.
Deciphering complement receptor type 1 interactions with recognition proteins of the lectin complement pathway.
Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses.
Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages.
Structural insights into the initiating complex of the lectin pathway of complement activation.
Association of low levels of mannan-binding protein with a common defect of opsonisation.
Oligomerization of Mannan-binding Lectin Dictates Binding Properties and Complement Activation.
C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules.
C1q/TNF-Related Protein 6 Is a Pattern Recognition Molecule That Recruits Collectin-11 from the Complement System to Ligands.
A reference map of the human binary protein interactome.
Complement Activation and Thrombin Generation by MBL Bound to β2-Glycoprotein I.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules.
Isolation and characterization of a mannan-binding protein from human serum.
Structure and function of mannan-binding proteins isolated from human liver and serum.
Binding of mannan-binding protein to various bacterial pathogens of meningitis.
A second serine protease associated with mannan-binding lectin that activates complement.
MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa
Conversion of C4 into C4a and C4b
Conversion of C2 into C2a and C2b
MBL2 curator research notes (this review)
FutureHouse Falcon deep-research report for MBL2 (P11226)