Gene Ontology annotation through association of InterPro records with GO terms.

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.

Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods.

Activation-induced ubiquitination of the T cell antigen receptor.

Five novel antigens illustrate shared phenotype between mouse thymic stromal cells, thymocytes, and peripheral lymphocytes.

Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif.

Stoichiometry of the murine gammadelta T cell receptor.

Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation.

Co-association of CD3 zeta with a receptor (CD16) for IgG Fc on human natural killer cells.

Transmembrane features governing Fc receptor CD16A assembly with CD16A signaling adaptor molecules.

Regulatory mechanisms in T cell receptor signalling.

T cell receptor signaling for γδT cell development.

Structural basis of assembly of the human T cell receptor-CD3 complex.

A new subunit of the human T-cell antigen receptor complex.

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.

Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.

Physical and functional association of p56lck with Fc gamma RIIIA (CD16) in natural killer cells.

Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro.

Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model.

Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility.

The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.

Phosphorylation of ITAM motifs in CD3 complexes

Phosphorylation of ZAP-70 by Lck

Activation of ZAP-70

Phosphorylation of SLP-76

Phosphorylation of TBSMs in LAT

Phosphorylation of PLC-gamma1

Recruitment of ZAP-70 to phosphorylated ITAMs

Phosphorylation and activation of PLCG

Recruitment of PLCgamma to membrane

PI3K phosphorylates PIP2 to PIP3

Release of PLCG from FCGR

PI3K binds to p-6Y-SYK

Activation of RAC1 by VAV

Recruitment of SYK to phosphorylated ITAMs

Phosphorylation of VAV

Cross-linking of FCGRIIIA with IgG-coated Ag

Recruitment of VAV1 to p-6Y-SYK

Sequestering and phosphorylation Fc gamma receptors in the lipid rafts

Activation of RAC1 by CRKII:DOCK180:ELMO

Role of myosins in phagosome formation

Recruitment of CRKII:DOCK180:ELMO complex to FCGR

Dephosphorylation of CD3-zeta by PD-1 bound phosphatases

PTPN22 dephosphorylates ZAP70

Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK

Recruitment of PLCgamma to membrane due to FCGR3A effect

Release of PLCG from FCGR3A

SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers

Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers

Phosphorylation and activation of PLCG due to FCGR3A effect

p-6Y-SYK phosphorylates VAV1,2,3

CRKII:DOCK180:ELMO binds FCGR3A

DOCK180 exchanges GTP for GDP on RAC1:GDP

p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP

VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK

IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole

Nef mediated activation of the T-cell receptor

TCR complex interacts with peptide antigen-presenting MHC Class I

Dephosphorylation of Lck-pY505 by CD45

Inactivation of Lck by Csk

Activation of Lck

Change of PKC theta conformation

viral HA binds NCRI

NCR3LG1 binds NCR3

CMVPP65 binds NCR3

TCR binds self-lipid-based antigen via CD1

TCR binds microbial lipid-based antigen via CD1

Inactivation of LCK by PTPN22

Opsonized leishmania amastigote binds FCGR3

IgG:Lma antigens binds FCGR3A:CD3 dimers

Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding.

Alternative modes of binding of proteins with tandem SH2 domains.

Peptide microarrays for the detection of molecular interactions in cellular signal transduction.

Identification of substrates of human protein-tyrosine phosphatase PTPN22.

T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation.

The transmembrane adaptor protein SIT inhibits TCR-mediated signaling.

The adaptor protein SAP directly associates with CD3ζ chain and regulates T cell receptor signaling.

End-binding protein 1 controls signal propagation from the T cell receptor.

β-Arrestin-1 mediates the TCR-triggered re-routing of distal receptors to the immunological synapse by a PKC-mediated mechanism.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity.

Association between mitogen-activated protein kinase and the zeta chain of the T cell receptor (TcR) with the SH2,3 domain of p56lck. Differential regulation by TcR cross-linking.

Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases.

Mechanism of activation for Zap-70 catalytic activity.

Interaction between the SH2 domains of ZAP-70 and the tyrosine-based activation motif 1 sequence of the zeta subunit of the T-cell receptor.

The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor.

CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.

BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression.

A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.

A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling.

Cyberian deep research on CD247 function