moaC (P0A738) notes, E. coli K-12

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Identity

• UniProt P0A738, cyclic pyranopterin monophosphate synthase, EC 4.6.1.17; synonym chlA3;
  b0783. Third gene of the moaABCDE operon. MoaC family (HAMAP MF_01224, TIGR00581, Pfam PF01967).
• Homohexamer, trimer of dimers; active site at the dimer interface
  PMID:10903949.

Function

• MoaC converts the MoaA product 3',8-cH2GTP to cPMP
  PMID:25941396.
  Kinetics (KM 0.21 uM, kcat 0.56 min-1) and alanine-scan mutants (D128A, K51A, H77A, E112A,
  K131A abolish activity) are in UniProt from this paper.
• Same division of labour in S. aureus PMID:23627491.

Curation decisions

• GO:0005515 (RplA co-purification, PMID:15690043): REMOVE per protein-binding policy.
• GO:0032991 and GO:0042802 (hexamer): KEEP_AS_NON_CORE; no specific complex term exists.
• GO:0061799 IDA/IEA and GO:0006777 IEA/IMP: ACCEPT. Core MF GO:0061799.
• Verdicts aligned with genes/PSEPK/moaC (ortholog Q88NC0) and genes/ECOLI/moaA.