Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons.
The JIP group of mitogen-activated protein kinase scaffold proteins.
c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity.
The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death.
Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.
Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1.
MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein.
c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK.
IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition.
Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells.
JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD.
Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.
Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun.
The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.
Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway.
The tyrosine kinase Syk regulates TPL2 activation signals.
Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases.
Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26.
Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling.
Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation.
Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1.
Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation.
3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis.
Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein.
Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1.
Crystal structure of SCCA1 and insight about the interaction with JNK1.
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.
A selective small-molecule inhibitor of c-Jun N-terminal kinase 1.
Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
JNK1 phosphorylates SIRT1 and promotes its enzymatic activity.
Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells.
JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis.
A critical step for JNK activation: isomerization by the prolyl isomerase Pin1.
JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress.
A directed protein interaction network for investigating intracellular signal transduction.
HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms.
Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling.
JNK regulates the photic response of the mammalian circadian clock.
Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.
Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly.
The protein interaction landscape of the human CMGC kinase group.
SASH1 is a scaffold molecule in endothelial TLR4 signaling.
Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors.
Regulation of autophagy by Beclin 1 in the heart.
HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth.
JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation.
MicroRNA-143-3p promotes human cardiac fibrosis via targeting sprouty3 after myocardial infarction.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
CLDN6 inhibits breast cancer metastasis through WIP-dependent actin cytoskeleton-mediated autophagy.
Multimodal cell maps as a foundation for structural and functional genomics.
Selective interaction of JNK protein kinase isoforms with transcription factors.
Activation of BIM and translocation to mitochondria
Phosphorylation of DLC2 by MAPK8
Activation of BMF and translocation to mitochondria
Phosphorylation of BIM by JNK
Phosphorylated MAPKs phosphorylate ATF-2
Activated JNKs phosphorylate c-JUN
Phosphorylation of human JNKs by activated MKK4/MKK7
NRAGE signals death through JNK
Active JNK moves to the nucleus and phosphorylates different transcription factors
JNK phosphorylates BIM, BAD and other targets
GTP-bound RAC contributes to JNK activation
Fc epsilon receptor (FCERI) signaling
Activated human JNKs migrate to nucleoplasm
APBB1 and MAPK8 bind diphosphorylated H2AFX
GTP-bound RAC1 contributes to MAPK8 activation
p-T,Y-MAPK8 translocates from the cytosol to the nucleoplasm
Activated JNK phosphorylates c-JUN
NPM1-ALK-dependent MAPK8,9 phosphorylation
p-T,Y MAPK8,9 translocate to the nucleus
UniProtKB/Swiss-Prot entry P45983 (MK08_HUMAN)
Falcon deep research report on MAPK8