Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on inter-ontology links
A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans.
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PKD-2 is the C. elegans homolog of human PKD2
"A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans."
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PKD-2 is localized to the same male-specific neurons as LOV-1
"A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans."
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PKD-2 functions in sensory neurons of rays, hook, and head
"A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans."
The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway.
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lov-1 and pkd-2 act in the same pathway
"The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway."
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Mutations result in identical male sensory behavioral defects
"The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway."
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PKD-2::GFP concentrated in cilia and cell bodies
"The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway."
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Cilia are structurally normal in pkd-2 mutants
"The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway."
Towards understanding the polycystins.
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lov-1 and pkd-2 participate in a single genetic pathway
"Towards understanding the polycystins."
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LOV-1 and PKD-2 localize to ends of sensory neurons
"Towards understanding the polycystins."
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Polycystins act as sensors of the extracellular environment
"Towards understanding the polycystins."
ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling.
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ATP-2 colocalizes with LOV-1 and PKD-2 in cilia
"ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling."
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atp-2, lov-1, and pkd-2 act in the same molecular pathway
"ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling."
Functional characterization of the C. elegans nephrocystins NPHP-1 and NPHP-4 and their role in cilia and male sensory behaviors.
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NPHP-1 and NPHP-4 colocalize with PKD-2 in male-specific sensory cilia
"Functional characterization of the C. elegans nephrocystins NPHP-1 and NPHP-4 and their role in cilia and male sensory behaviors."
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Nephrocystins facilitate ciliary sensory signal transduction
"Functional characterization of the C. elegans nephrocystins NPHP-1 and NPHP-4 and their role in cilia and male sensory behaviors."
Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans.
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PKD-2 is an intracellular Ca2+ release channel
"Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans."
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PKD-2 required for normal Ca2+ response patterns
"Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans."
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PKD-2 creates brief cytosolic Ca2+ transients with increased amplitude
"Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans."
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PKD-2 works with IP3 and ryanodine receptors in the ER
"Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans."
Casein kinase II and calcineurin modulate TRPP function and ciliary localization.
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CK2 phosphorylates PKD-2 at Ser-534
"Casein kinase II and calcineurin modulate TRPP function and ciliary localization."
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Calcineurin dephosphorylates PKD-2
"Casein kinase II and calcineurin modulate TRPP function and ciliary localization."
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Phosphorylation state regulates ciliary localization
"Casein kinase II and calcineurin modulate TRPP function and ciliary localization."
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Phospho-defective S534A localizes to cilia
"Casein kinase II and calcineurin modulate TRPP function and ciliary localization."
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Phospho-mimetic S534D is absent from cilia
"Casein kinase II and calcineurin modulate TRPP function and ciliary localization."
General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia.
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PKD-2 moves bidirectionally in dendritic compartment
"General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia."
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UNC-101/AP-1 directs PKD-2 to dendritic particles
"General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia."
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LOV-1 required for PKD-2 stabilization in cilia
"General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia."
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Cell-type specific factors required for dendritic targeting
"General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia."
STAM and Hrs down-regulate ciliary TRP receptors.
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STAM-1A interacts with LOV-1
"STAM and Hrs down-regulate ciliary TRP receptors."
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STAM-Hrs directs LOV-1-PKD-2 for lysosomal degradation
"STAM and Hrs down-regulate ciliary TRP receptors."
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Overexpression removes PKD-2 from cilia
"STAM and Hrs down-regulate ciliary TRP receptors."
Distinct protein domains regulate ciliary targeting and function of C. elegans PKD-2.
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Transmembrane region sufficient for ciliary targeting
"Distinct protein domains regulate ciliary targeting and function of C. elegans PKD-2."
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Cytosolic tails regulate cell body localization
"Distinct protein domains regulate ciliary targeting and function of C. elegans PKD-2."
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PKD-2 colocalizes with OSM-9 TRPV channel
"Distinct protein domains regulate ciliary targeting and function of C. elegans PKD-2."
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Human PC-2 partially rescues pkd-2 mutants
"Distinct protein domains regulate ciliary targeting and function of C. elegans PKD-2."
Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport.
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PKD-2::GFP used as ciliary marker
"Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport."
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Localization to cilia and sensory dendrites
"Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport."
Deep research report on pkd-2