Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate.
Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells.
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
Androgen receptor interacts with a novel MYST protein, HBO1.
Beta-catenin affects androgen receptor transcriptional activity and ligand specificity.
DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor.
Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1.
Conformational analysis of the androgen receptor amino-terminal domain involved in transactivation. Influence of structure-stabilizing solutes and protein-protein interactions.
Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription.
DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.
A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4.
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Tcf4 associates with the AR DNA-binding domain and cellular receptor.
"Tcf4 bound specifically to a glutathione
S-transferase-ARDBD fusion protein and could be coimmunoprecipitated with
beta-catenin and transfected AR or endogenous AR in prostate cancer cells."
Isolation and identification of L-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hybrid system.
Identification of glucocorticoid receptor domains involved in transrepression of transforming growth factor-beta action.
The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway.
Androgen regulation of the human FERM domain encoding gene EHM2 in a cell model of steroid-induced differentiation.
Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation.
The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor.
Negative modulation of androgen receptor transcriptional activity by Daxx.
Androgen receptor function is modulated by the tissue-specific AR45 variant.
Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors.
hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes.
Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor.
Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1.
Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation.
Androgen receptor auto-regulates its expression by a negative feedback loop through upregulation of IFI16 protein.
Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription.
Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1.
Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells.
Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor.
A novel function of caspase-8 in the regulation of androgen-receptor-driven gene expression.
Control of prostate cell growth: BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in Smad1.
Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor.
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression.
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AR associates with JMJD2C and assembles with demethylases on target chromatin.
"androgen receptor, JMJD2C
and LSD1 assemble on chromatin"
A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR.
Androgen-dependent gene expression of prostate-specific antigen is enhanced synergistically by hypoxia in human prostate cancer cells.
Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor.
DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells.
PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor.
Peroxiredoxin 1 interacts with androgen receptor and enhances its transactivation.
Interaction between the androgen receptor and a segment of its corepressor SHP.
Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway.
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Treatment enhances Akt/MDM2/AR complex formation.
"Antibody pull-down results also indicated that isosilybin B
treatment enhances the formation of complex between Akt, Mdm2 and AR"
Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells.
TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells.
Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.
Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes.
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Antagonists induce AR association with prohibitin and BRG1.
"Androgen antagonists induce recruitment of prohibitin and BRG1 to endogenous
AR-responsive promoters and induce a physical association between AR and
prohibitin and BRG1."
FOXP1 is an androgen-responsive transcription factor that negatively regulates androgen receptor signaling in prostate cancer cells.
A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth.
Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination.
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RNF6 was identified as an AR-associated E3 ligase.
"We have
identified a ubiquitin E3 ligase, RNF6, as an AR-associated protein in a
proteomic screen."
The histone methyltransferase, NSD2, enhances androgen receptor-mediated transcription.
Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists.
Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3' untranslated region.
TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells.
Androgen receptor-dependent transactivation of growth arrest-specific gene 6 mediates inhibitory effects of testosterone on vascular calcification.
TAF1 differentially enhances androgen receptor transcriptional activity via its N-terminal kinase and ubiquitin-activating and -conjugating domains.
An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling.
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor.
FBI-1 functions as a novel AR co-repressor in prostate cancer cells.
BTG2 is an LXXLL-dependent co-repressor for androgen receptor transcriptional activity.
Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation.
The androgen receptor induces integrin α6β1 to promote prostate tumor cell survival via NF-κB and Bcl-xL Independently of PI3K signaling.
Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors.
MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling.
Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells.
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MJC13 inhibits release of AR from its Hsp90/FKBP52 complex.
"MJC13, inhibits AR function by preventing hormone-dependent
dissociation of the Hsp90-FKBP52-AR complex"
Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP.
Targeting androgen receptor in estrogen receptor-negative breast cancer.
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Nuclear AR and beta-catenin associate in the studied human breast-cancer cells.
"We detected the physical interaction between AR and β-catenin in the nuclear extracts of MDA-MB-453 breast cancer cells by co-immunoprecipitation"
The beta-catenin binding protein ICAT modulates androgen receptor activity.
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.
Structural basis of coactivation of liver receptor homolog-1 by β-catenin.
A transcriptional repressor co-regulatory network governing androgen response in prostate cancers.
The mutational landscape of lethal castration-resistant prostate cancer.
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Reverse IP confirms AR association with MLL proteins, ASH2L and FOXA1.
"Reverse immunoprecipitation confirmed interactions between AR and MLL, MLL2, ASH2L and FOXA1"
The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man.
The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity.
Ski-interacting protein (SKIP) interacts with androgen receptor in the nucleus and modulates androgen-dependent transcription.
CCAR1 promotes chromatin loading of androgen receptor (AR) transcription complex by stabilizing the association between AR and GATA2.
The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling.
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
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AR phosphopeptides bind selected SH2 domains in vitro, with site-specific affinity limits.
"The peptide derived from Tyr(P)-362 interacted with SH2 domains from SRC, RASA1, PLCG1, and the PI3KR phosphatidylinositol kinase regulatory subunits."
Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer.
Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis.
Loss of Androgen-Regulated MicroRNA 1 Activates SRC and Promotes Prostate Cancer Bone Metastasis.
DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis.
Resistance to docetaxel in prostate cancer is associated with androgen receptor activation and loss of KDM5D expression.
Molecular cloning of human and rat complementary DNA encoding androgen receptors.
Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.
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Affinity purification independently confirms KMT2A association beyond proximity labeling.
"Using an affinity purification approach, we confirmed the previously reported association between AR and MED1 or KMT2A"
Low amounts of heavy water increase the phase separation propensity of a fragment of the androgen receptor activation domain.
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A purified human AR activation-domain fragment forms fusion-capable droplets in vitro.
"We observed that Tau‐5* indeed undergoes LLPS, as shown in Figure 1(b) , forming droplets capable of fusing"
Targeting androgen receptor phase separation to overcome antiandrogen resistance.
Formation of NR-MED1 Coactivator Complex
Formation of NR-NCOR Corepressor Complex
PIAS1,2-1 SUMOylates AR with SUMO1
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus
Phosphorylated PKN1 binds androgen receptor (AR)
p-T774-PKN1:AR:Androgen complex translocates to the nucleus
PKN1 stimulates association of AR with NCOA2
PKN1:AR complex binds promoters of KLK2 and KLK3 genes
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters
Demethylase KDM4C binds KLK2 and KLK3 promoters
KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters
KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters
Demethylase KDM1A binds KLK2 and KLK3 promoters
KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters
USP12, USP26 deubiquitinate AR
Androgens binds AR (in the HSP90 chaperone complex)
Manual AR primary-source reading and annotation scope