Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1.
The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion.
The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles.
A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Conductin/axin2 and Wnt signalling regulates centrosome cohesion.
SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer.
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
3D-structured illumination microscopy provides novel insight into architecture of human centrosomes.
Primary ciliogenesis requires the distal appendage component Cep123.
The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.
Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion.
MDM1 is a microtubule-binding protein that negatively regulates centriole duplication.
Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.
A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.
Novel Candidate Genes and a Wide Spectrum of Structural and Point Mutations Responsible for Inherited Retinal Dystrophies Revealed by Exome Sequencing.
CCDC102B functions in centrosome linker assembly and centrosome cohesion.
Cep44 functions in centrosome cohesion by stabilizing rootletin.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
A proteome-scale map of the SARS-CoV-2-human contactome.
cNap1 bridges centriole contact sites to maintain centrosome cohesion.
C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2.
AJUBA facilitates AURKA autophosphorylation
AJUBA binds centrosome-associated AURKA
AURKA phosphorylates PLK1
BORA binds PLK1 and AURKA
Plk1-mediated phosphorylation of Nlp
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
Loss of C-Nap-1 from centrosomes
Dissociation of Phospho-Nlp from the centrosome
Recruitment of Plk1 to centrosomes
Association of NuMA with microtubules
Recruitment of CDK11p58 to the centrosomes
Translocation of NuMA to the centrosomes
RAB3IP stimulates nucleotide exchange on RAB8A
C2CD3 binds the mother centriole
C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
CP110 and CEP97 dissociate from the centriole
The distal appendage proteins recruit TTBK2
Recruitment of transition zone proteins
MARK4 binds ODF2 in the centriole
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
TPX2 binds AURKA at centrosomes
TPX2 promotes AURKA autophosphorylation
Nip2/centrobin may be a substrate of Nek2 that is required for proper spindle assembly during mitosis in early mouse embryos.
Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification.
Functional characterization of CEP250 variant identified in nonsyndromic retinitis pigmentosa.
CEP250 source-specific interaction, compartment and detection evidence