Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain.
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DPYSL5/CRAM is a CRMP-family protein (~57% identical to dihydropyrimidinase, 50-51% to CRMPs) that associates with CRMP3 and protein-tyrosine kinases.
"a novel CRMP3-associated protein, designated CRAM ... shows 57% identity with dihydropyrimidinase, and shows 50-51% identity with CRMPs"
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Brain-specific expression, highest in fetal/neonatal brain and up-regulated during neuronal differentiation.
"The expression of CRAM is brain-specific, is high in fetal and neonatal rat brain ... up-regulated during neuronal differentiation"
Missense variants in DPYSL5 cause a neurodevelopmental disorder with corpus callosum agenesis and cerebellar abnormalities.
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Missense variants in DPYSL5 cause a neurodevelopmental disorder; DPYSL5 controls dendrite/neurite outgrowth.
"Missense variants in DPYSL5 cause a neurodevelopmental disorder with corpus callosum agenesis and cerebellar abnormalities."
A proteome-scale map of the human interactome network.
Architecture of the human interactome defines protein communities and disease networks.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Other semaphorin interactions (CRMP signalling).
CRMP phosphorylation / semaphorin signalling reaction.
CRMP signalling reaction.
UniProt entry Q9BPU6 (DPYSL5)
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DPYSL5 lacks the metal-cofactor-binding residues essential for dihydropyrimidinase activity.
"Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity."
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DPYSL5 belongs to the metallo-dependent hydrolase superfamily and negatively regulates dendrite outgrowth.
"Belongs to the metallo-dependent hydrolases superfamily."