Annotation inferences using phylogenetic trees
Manual transfer of GO annotation data to genes by curator judgment of sequence model
SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56.
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Fbxo42 (CG6758) forms an SCF complex with SkpA and Cul1 in ovaries and is required for synaptonemal-complex assembly and maintenance and for karyosome formation.
"Depletion of CG6758 (which we call Fbxo42) prevented assembly of the fully filamentous synaptonemal complex and prematurely disassembled the partially formed structure"
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Fbxo42 depletion raises levels of the PP2A-B56 subunit Wrd, and Wrd overexpression phenocopies the synaptonemal-complex defect.
"In the Fbxo42 depletion, GFP-Wrd showed significant increases in region 2 of the germarium"
Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling.
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Fbxo42 binds SkpA through its F-box and binds Ataxin-2, promoting Ataxin-2 ubiquitylation (candidate acceptor C244) and proteasomal degradation.
"We conclude that Fbxo42 promotes the degradation of Ataxin-2 by mediating the ubiquitylation of the C244 residue."
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Under ER or arsenite stress Fbxo42 is recruited to Ataxin-2 granules, and degradation of Ataxin-2 is required for accumulation of Xbp1s protein.
"degradation of Ataxin-2 granules by Fbxo42 is required for the accumulation of Xbp1spliced protein"
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Fbxo42 acts downstream of UPR activation but upstream of the apoptotic machinery.
"indicating that Fbxo42 acts downstream of UPR activation but upstream of the apoptotic machinery"
DROME/Fbxo42/Fbxo42-uniprot.txt
Fbxo42 falcon deep research report