Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease.
The prodomain of caspase-1 enhances Fas-mediated apoptosis through facilitation of caspase-8 activation.
Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis.
Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.
Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing.
Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins.
CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease.
Molecular cloning of the interleukin-1 beta converting enzyme.
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.
A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.
INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation.
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.
PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.
Nucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activation.
Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.
The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion.
The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.
Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death.
Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation.
NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.
Active caspase-1 is a regulator of unconventional protein secretion.
A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide.
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.
Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells.
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.
Inflammasomes in health and disease.
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome.
Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes.
Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.
Cell volume regulation modulates NLRP3 inflammasome activation.
CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration.
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.
Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex.
A proteome-scale map of the human interactome network.
Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization.
The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus.
Inflammasomes: mechanism of action, role in disease, and therapeutics.
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.
Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.
Identification of a monocyte specific pre-interleukin 1 beta convertase activity.
Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation.
NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma.
Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection.
Inflammasome activation and assembly at a glance.
The AIM2 inflammasome: Sensor of pathogens and cellular perturbations.
Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
SERPINB1-mediated checkpoint of inflammatory caspase activation.
Expression of a PYCARD/ASC variant lacking exon 2 in Japanese patients with palindromic rheumatism increases interleukin-1β secretion.
Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis.
A reference map of the human binary protein interactome.
Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage.
Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation.
The human disease-associated gene ZNFX1 controls inflammation through inhibition of the NLRP3 inflammasome.
Cleavage of poly(ADP-ribose) polymerase by interleukin-1 beta converting enzyme and its homologs TX and Nedd-2.
Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities.
Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells.
Formation of caspase-1 p10/p20 dimer
CTSG cleaves CASP1(1-404)
Caspase-1 active tetramer formation
Interleukin-1 family precursors are cleaved by caspase-1
TP53 family members stimulate CASP1 expression
PYCARD recruits procaspase-1 via CARD
IL37 binds 2x(CASP1(120-197):CASP1(317-404))
IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37
IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404)
SARS-CoV-1 3a binds to caspase-1