Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins in living cells
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe.
Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette.
The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane.
BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells.
Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.
Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1.
Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.
Involvement of caveolin-2 in caveolar biogenesis in MDCK cells.
Caveolae and caveolin-1 in human term villous trophoblast.
Association of the calpain/calpastatin network with subcellular organelles.
Sterol carrier protein-2 directly interacts with caveolin-1 in vitro and in vivo.
N-terminal processing and modifications of caveolin-1 in caveolae from human adipocytes.
Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells.
Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current.
Caveolin-1 expression is essential for proper nonshivering thermogenesis in brown adipose tissue.
Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate.
Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA).
Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.
Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression.
The shedding activity of ADAM17 is sequestered in lipid rafts.
Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.
Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells.
Identification of a novel inhibitor of differentiation-1 (ID-1) binding partner, caveolin-1, and its role in epithelial-mesenchymal transition and resistance to apoptosis in prostate cancer cells.
Caveolin-1 and caveolin-3 form heterooligomeric complexes in atrial cardiac myocytes that are required for doxorubicin-induced apoptosis.
Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells.
The regulation of the cardiac potassium channel (HERG) by caveolin-1.
Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells.
SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function.
The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1.
SDPR induces membrane curvature and functions in the formation of caveolae.
TLR4-mediated expulsion of bacteria from infected bladder epithelial cells.
Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy.
Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence.
Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1.
MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation.
The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer.
A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.
Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements.
Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1.
Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema.
The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus.
Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma.
Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations.
Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells.
Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1.
The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation.
The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.
The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling.
Downregulation of miR-138 sustains NF-κB activation and promotes lipid raft formation in esophageal squamous cell carcinoma.
Prominin-2 expression increases protrusions, decreases caveolae and inhibits Cdc42 dependent fluid phase endocytosis.
Molecular composition and ultrastructure of the caveolar coat complex.
Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex.
Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux.
Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization.
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension.
Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells.
The Niemann-Pick C1 and caveolin-1 proteins interact to modulate efflux of low density lipoprotein-derived cholesterol from late endocytic compartments.
New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.
Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae.
Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization.
c-Src/Cav1-dependent activation of the EGFR by Dsg2.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Interactomes of SARS-CoV-2 and human coronaviruses reveal host factors potentially affecting pathogenesis.
A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.
Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo.
Interaction between caveolin-1 and the reductase domain of endothelial nitric-oxide synthase. Consequences for catalysis.
eNOS:Caveolin-1 complex binds to CaM
HSP90 binds eNOS:Caveolin-1:CaM complex
Caveolin-1 dissociates from eNOS:CaM:HSP90 complex
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP
NOSTRIN mediated translocation of eNOS from plasma membrane
eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2
eNOS associates with Caveolin-1
eNOS:Caveolin-1 complex binds to Nostrin
Tyrosine is monoiodinated
Two DITs combine to form thyroxine
DIT and MIT combine to form triiodothyronine
WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6
RAC1 binds effectors at the plasma membrane
CDC42 GDIs block activation of CDC42
PalmS-ESRs:CAVs translocate to plasma membrane
CAV1 gene expression is stimulated by FOXO1,FOXO3
SARS-CoV-1 3a tetramer binds to CAV1
Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy.
Heterozygous CAV1 frameshift mutations (MIM 601047) in patients with atypical partial lipodystrophy and hypertriglyceridemia.
Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension.
Molecular architecture of the human caveolin-1 complex.
Caveolin assemblies displace one bilayer leaflet to organize and bend membranes.
UniProtKB Q03135 (CAV1_HUMAN): reviewed human caveolin-1