Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Electronic Gene Ontology annotations created by ARBA machine learning models

Integral and associated lysosomal membrane proteins.

PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.

A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.

Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15.

Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation.

Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1.

Structural basis for membrane remodeling by the AP5-SPG11-SPG15 complex.

Defective autophagy in spastizin mutated patients with hereditary spastic paraparesis type 15.