Gene Ontology annotation through association of InterPro records with GO terms

InterPro domain mappings support conserved molecular features but can over-project broad DNA/lipid/dimerization functions without Arabidopsis-specific evidence.

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

UniProt subcellular-location mappings provide conservative localization support when consistent with transcription-factor biology.

GO_REF:0000108

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Logical inference supplies broad transcriptional-regulation process annotations from molecular function terms; these should often be narrowed to the gene-specific regulatory context.

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

ARBA machine-learning annotations should be treated as broad predictions and retained only where consistent with experimental Arabidopsis evidence.

GO_REF:0000122

AtSubP analysis

AtSubP prediction supports localization hypotheses but is weaker than direct localization experiments.

PMID:11118137

Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.

PMID:11844112

Entopically additive expression of GLABRA2 alters the frequency and spacing of trichome initiation.

Ectopic GL2 expression alters trichome initiation frequency and spacing.

PMID:16581911

Transcriptional and posttranscriptional regulation of transcription factor expression in Arabidopsis roots.

PMID:25533953

An Arabidopsis gene regulatory network for secondary cell wall synthesis.

A yeast-one-hybrid network detected GL2 binding to secondary-cell-wall gene promoters; this supports cis-regulatory binding but is not central epidermal GL2 biology.

PMID:26486447

GLABRA2 Directly Suppresses Basic Helix-Loop-Helix Transcription Factor Genes with Diverse Functions in Root Hair Development.

GL2 directly suppresses root-hair-promoting bHLH transcription factor genes through promoter binding.

PMID:28526410

Adaptor proteins GIR1 and GIR2. I. Interaction with the repressor GLABRA2 and regulation of root hair development.

GIR1/GIR2 interact with GL2 and GL2 localizes to the nucleus in root hair regulatory assays.

PMID:7926739

The GLABRA2 gene encodes a homeo domain protein required for normal trichome development in Arabidopsis.

GL2 encodes a homeodomain protein required for normal trichome development.

PMID:8620852

The homeobox gene GLABRA2 is required for position-dependent cell differentiation in the root epidermis of Arabidopsis thaliana.

GL2 is required for position-dependent root epidermal cell differentiation and represses root hair fate in non-hair cells.

file:ARATH/GL2/GL2-deep-research-falcon.md

Falcon deep research for Arabidopsis GL2

GL2 is a class IV HD-ZIP transcription factor downstream of MBW complexes and a central regulator of trichome, root non-hair, and seed coat epidermal cell fates.
GL2 recognizes L1 box-like cis-elements in target promoters and acts in the nucleus as a DNA-binding transcriptional regulator.

file:ARATH/GL2/GL2-uniprot.txt

UniProt record for Arabidopsis GL2

UniProt identifies GL2/P46607 as a class IV HD-ZIP homeobox transcription factor required for trichome maturation, trichome initiation spacing, and negative regulation of root hair development.

file:interpro/panther/PTHR45654/PTHR45654-entries.csv

PANTHER PTHR45654 family entries for Arabidopsis GL2

PTHR45654 places GL2 in the homeobox-leucine zipper protein family, supporting conserved HD-ZIP DNA-binding transcription factor activity while leaving GL2-specific epidermal functions to Arabidopsis evidence.