Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Pseudomonas aeruginosa thiol peroxidase protects against hydrogen peroxide toxicity and displays atypical patterns of gene regulation.
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Purified Tpx is a thioredoxin-dependent peroxidase acting on H2O2 and organic hydroperoxides.
"The enzyme catalyzes thioredoxin-dependent peroxidation and can utilize organic hydroperoxides and H(2)O(2) as substrates."
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A tpx deletion mutant is hypersensitive to 0.5 mM H2O2, complemented in trans.
"The Δ tpx mutant was more than 10-fold more sensitive to 0.5 mM H 2 O 2 than the PAO1 wild type"
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Tpx lacks a functional periplasmic export signal and is probably cytoplasmic.
"we conclude that the protein is not secreted to the periplasm via a typical signal sequence, greatly decreasing the likelihood that this protein is located in the periplasm"
UniProt entry P57668 (TPX_PSEAE)