Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Combined Automated Annotation using Multiple IEA Methods.
Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals.
Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control.
BRCA2 and homologous recombination.
Highlight: BRCA1 and BRCA2 proteins in breast cancer.
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.
BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage.
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair.
BRCA2 suppresses cell proliferation via stabilizing MAGE-D1.
WDRPUH, a novel WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and involved in cell proliferation.
Analysis of albumin-associated peptides and proteins from ovarian cancer patients.
DSS1 is required for the stability of BRCA2.
Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication.
Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division.
Analysis of PALB2/FANCN-associated breast cancer families.
Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats.
Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2.
Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1.
FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3.
Resistance to therapy caused by intragenic deletion in BRCA2.
The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51.
PALB2 is an integral component of the BRCA complex required for homologous recombination repair.
PALB2 regulates recombinational repair through chromatin association and oligomerization.
Structural basis for recruitment of BRCA2 by PALB2.
The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange.
Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.
Purified human BRCA2 stimulates RAD51-mediated recombination.
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.
BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping.
Homologous recombination proteins are associated with centrosomes and are required for mitotic stability.
A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor.
Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51.
A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay.
Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2.
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair.
APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.
A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization.
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.
Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor.
FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51.
Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability.
Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.
Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance.
Two Missense Variants Detected in Breast Cancer Probands Preventing BRCA2-PALB2 Protein Interaction.
HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment.
The BRCA2 is a histone acetyltransferase.
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.
BRCA2 associates with acetyltransferase activity when bound to P/CAF.
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Gene Ontology annotation based on curation of immunofluorescence data
Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.
The role of BRCA2 in replication-coupled DNA interstrand cross-link repair in vitro.
BRCA1 is secreted and exhibits properties of a granin.
Transcriptional activation functions in BRCA2.
CHEK1 phosphorylates BRCA2
BCDX2 complex stabilizes RAD51 filament
CX3 complex binds D-loop structures
BLM mediates dissolution of double Holliday junction
MUS81:EME1,EME2 cleaves D-loop
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
Ligation of DNA and formation of Holliday structures following repair synthesis
RAD51 binds BRCA2 at resected DNA DSBs
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
D-loop dissociation and strand annealing
D-loop extension by DNA polymerases
D-loop formation mediated by PALB2, BRCA2 and RAD51
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C
Defective BRCA2 does not translocate to the nucleus
BRCA2 translocates to the nucleus
BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51
Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding
BRCA2 mutants do not bind SEM1 (DSS1)
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
Replication fork reversal triggers fork degradation in BRCA2-defective cells.
BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA.
Deep research on BRCA2 function