Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Towards a proteome-scale map of the human protein-protein interaction network.
K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1.
MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks.
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MERIT40 is essential for BRCA1-Rap80 complex integrity.
"Here, we identify MERIT40 (Mediator of Rap80 Interactions and Targeting 40 kD)/(C19orf62) as a Rap80-associated protein that is essential for BRCA1-Rap80 complex protein interactions, stability, and DSB targeting."
MERIT40 facilitates BRCA1 localization and DNA damage repair.
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.
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NBA1 is a BRCA1-A component.
"Proteomic analysis revealed that NBA1 is a component of the BRCA1 A complex, which also contains Brca1/Bard1, Abra1, RAP80, BRCC36, and BRE."
Defining the human deubiquitinating enzyme interaction landscape.
Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex.
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes.
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.
BRCA1 tumor suppressor network: focusing on its tail.
A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses.
A proteome-scale map of the human interactome network.
Architecture of the human interactome defines protein communities and disease networks.
Metabolic control of BRISC-SHMT2 assembly regulates immune signalling.
Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
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BRISC contains two copies each of its core subunits.
"Analogous to BRCA1-A, the BRISC structure comprises two copies each of proteins BRCC36, ABRO1, BRE, MERIT40, and SHMT2α."
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
Formation of BRCA1-A complex at DNA DSBs
CHEK2 is recruited to DNA DSBs
CHEK2 phosphorylates BRCA1
RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
BRCA1-A complex deubiquitinates K63polyUb-histone H2A
BRISC complex deubiquitinates NLRP3
Phosphorylation of BRCA1-A complex at multiple sites by ATM
Phosphorylation and activation of CHEK2 by ATM
UniProt entry Q9NWV8 (BABA1_HUMAN)
Affinage mechanistic annotation for BABAM1 (human)
MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.
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MERIT40 acts early in ICL repair with RAP80 and the FA-BRCA network.
"These findings implicate MERIT40 in the earliest stages of ICL repair and define specific functional interactions between RAP80 complex-dependent ubiquitin recognition and the Fanconi anemia (FA)-BRCA ICL repair network."
MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs.
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Tankyrase is recruited to DSBs through MERIT40.
"We found that tankyrase is localized to DSBs through its interaction with MERIT40, and pharmacological inhibition of tankyrase sensitized human lung cancer cells to DNA-damaging anticancer agents."
MERIT40 Is an Akt Substrate that Promotes Resolution of DNA Damage Induced by Chemotherapy.
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MERIT40 is an Akt substrate after doxorubicin.
"We identify MERIT40, a component of the BRCA1-A DNA damage repair complex, as an Akt substrate that is phosphorylated following doxorubicin treatment."
RXXPEG motif of MERIT40 is required to maintain spindle structure and function through its interaction with Tankyrase1.
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MERIT40 binds the TNKS1 ARC-V domain via its RXXPEG motif.
"Here we demonstrated that MERIT40, a core component of BRISC complex, directly interacts with the RXXPEG motif in the ARC-V domain of Tankyrase1(TNKS1)."
WWOX binds MERIT40 and modulates its function in homologous recombination, implications in breast cancer.
Phosphoproteomic Analysis Defines BABAM1 as mTORC2 Downstream Effector Promoting DNA Damage Response in Glioblastoma Cells.
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mTORC2 regulates BABAM1 Ser29 phosphorylation to initiate the DDR.
"We demonstrated that pBABAM1 at Ser29 is regulated by mTORC2 to initiate DNA damage response, contributing to DNA repair and cancer cell survival."
Structural and functional characterization of the MERIT40 to understand its role in DNA repair.