AURKA notes

2026-10-05 review (PAINT, affinage)

• 154 GOA rows, reviewed with a rule-based builder (term → action) and quotes mainly from the extensively curated UniProt entry, plus row-specific papers.
• Core: S/T kinase activity, centrosome and spindle pole, mitotic spindle organization, centrosome separation and cycle, cilium disassembly at the basal body PMID:17604723.
• Over-annotated: chromosome passenger complex (IBA, an Aurora-B complex); response to wounding and liver regeneration (transgenic overexpression phenotypes, PMID:19435814); protein heterodimerization (the GADD45A NMR contact).
• MODIFY: protein S/T/Y kinase activity → S/T (no tyrosine activity reported). UNDECIDED: molecular function activator activity (EXP, a structure paper).
• Non-core: Aurora-B-type IBA rows (kinetochore, spindle midzone, regulation of cytokinesis), nuclear and perinuclear pools, basolateral and neuron projection (by similarity), and substrate-level outputs (HURP stability, Kif18b-MCAK, FOXP1/FBXL7, RALA mitochondrial fission, p53).
• 50 GO:0005515 IPIs: the PLK1 row becomes protein kinase binding; the rest are removed (TPX2, BORA, MYCN and others).
• PMID:23792191 (a GOA IPI source, N-Myc degradation by Aurora-A inhibitors) has an erratum; it is not quoted here.

2026-10-05 revision (reviewer round 1)

• Row-level evidence: each row's own cached reference is now quoted, e.g. PMID:18615013.
• The meiotic rows are kept as non-core on mouse oocyte evidence PMID:31895686.
• Cytosol is now non-core and centriole is accepted. The nuclear pool has a kinase-independent hnRNP K/MYC role (PMID:26782714).
• The IKBKB and MYCN IPIs stay removed: N-Myc stabilization is carried by GO:0031647.

2026-10-05 revision (reviewer round 2)

• Each row quote now addresses its own term. Where a cached abstract does not speak to a row, the row carries only UniProt support, and the reference note says so.
• MYCN IPIs were changed to GO:0008134 transcription factor binding PMID:25175806. IKBKB was changed to GO:0019901 PMID:17939994.