Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database

Combined Automated Annotation using Multiple IEA Methods

Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway.

Dec1 and Dec2 are regulators of the mammalian molecular clock.

DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter.

A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation.

DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1.

Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1.

Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis.

DEC1 modulates the circadian phase of clock gene expression.

The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors.

SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability.

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.

Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1.

A proteome-scale map of the human interactome network.

Widespread macromolecular interaction perturbations in human genetic disorders.

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

Circadian rhythmicity: A functional connection between differentiated embryonic chondrocyte-1 (DEC1) and small heterodimer partner (SHP).

Interleukin-6 Induces DEC1, Promotes DEC1 Interaction with RXRα and Suppresses the Expression of PXR, CAR and Their Target Genes.

An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.

Dec1 and CLOCK Regulate Na(+)/K(+)-ATPase β1 Subunit Expression and Blood Pressure.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

A reference map of the human binary protein interactome.

Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes.

Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms.

Defective T cell activation and autoimmune disorder in Stra13-deficient mice.

Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia.

Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes.

Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation.

Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection.

Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity.

Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self-renewal and identity.

The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8(+) T Cell Fitness and Functionality.

Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements.

Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system.

Stra13 homodimers repress transcription through class B E-box elements.

Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells.

Efferocytosis induces macrophage proliferation to help resolve tissue injury.

UniProtKB entry O14503 (BHLHE40_HUMAN)