Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Next-generation sequencing to generate interactome datasets.
Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.
Protein interactions of the transcription factor Hoxa1.
A proteome-scale map of the human interactome network.
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Host PDZ-containing proteins targeted by SARS-CoV-2.
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LNX2 was among the human PDZ proteins recognized by SARS-CoV and SARS-CoV-2 proteins in an in-vitro affinity-profiling screen.
"Six of them (TJP1, PTPN13, HTRA1, PARD3, MLLT4, LNX2) are also recognized by SARS-CoV while three (NHERF1, MAST2, RADIL) are specific to SARS-CoV-2 E protein."
Quantitative fragmentomics allow affinity mapping of interactomes.
Structural basis for the indispensable role of a unique zinc finger motif in LNX2 ubiquitination.
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Full-length human LNX2 uses UbcH5-family E2 enzymes for E3-ligase activity.
"We expressed the full-length LNX2 (FL-LNX2) and identified that the UbcH5 E2 family is involved in mediating the E3 ligase activity of LNX2 using the E2 profiling kit (Life Sensors) (Figure 1A)."
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Human NUMB is directly polyubiquitinated by full-length LNX2.
"We observed that human Numb acts as a substrate for FL-LNX2 and undergoes polyubiquitination (Figure 2A and 2B)."
The Lnx family proteins function as molecular scaffolds for Numb family proteins.
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Lnx2 binds Numb/Numblike and can oligomerize through multiple interaction modules.
"We isolated a novel mammalian protein, Lnx2, which interacts with mammalian Numb and Numblike."
Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8α and promote its ubiquitylation and endocytosis.
E3 ubiquitin ligases LNX1 and LNX2 localize at neuronal gap junctions formed by connexin36 in rodent brain and molecularly interact with connexin36.
E3 ubiquitin ligases LNX1 and LNX2 are major regulators of the presynaptic glycine transporter GlyT2.
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LNX1 and LNX2 regulate GlyT2 ubiquitination, abundance, and transport activity in neuronal models.
"Guided by an unbiased screening, we discovered that E3 ubiquitin ligase Ligand of Numb proteins X1/2 (LNX1/2) modulate the ubiquitination status of GlyT2."
Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.
UniProt record for human LNX2 (Q8N448)