RNR4 (P49723) notes

Module: dntp_de_novo_synthesis, role = inactive small-subunit partner (fungal Rnr4 type).

Evidence journal

• Catalytically inactive, lacks iron ligands, tyrosine dispensable PMID:9315671
• Folds/stabilises Rnr2 PMID:10716984; no iron PMID:10716984
• In vivo requirement for cofactor PMID:16285741
• RNR2 and RNR4 not interchangeable PMID:9315670
• Nuclear anchoring by Wtm1 PMID:18851834

Annotation decisions

• GO:0004748 rows with 'enables' (IEA, IGI, IMP) ACCEPTed, noting that 'contributes_to' is more accurate for this non-catalytic subunit.
• Oxidoreductase activity IEA (IPR012348): REMOVE (pseudoenzyme over-annotation).
• 17 protein binding rows: MODIFY to GO:0046982 for small-scale Rnr2 data; REMOVE others (Rnr1, Wtm1/Wtm2, high-throughput).
• GO:0106387 RCA: REMOVE.