Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Combined Automated Annotation using Multiple IEA Methods
Molecular evolution of the three short PGRPs of the malaria vectors Anopheles gambiae and Anopheles arabiensis in East Africa
Deep research summary for PGRPS3 in Anopheles gambiae
-
PGRP-S3 retains catalytic amidase residues unlike PGRP-S1
"short PGRPs S2 and S3 retain the canonical amidase signature motif(s) characteristic of Zn2+-dependent N-acetylmuramoyl-L-alanine amidases"
-
PGRP-S3 is a secreted, extracellular protein
"PGRP-S3, as a short PGRP, is therefore most likely secreted into the hemolymph or local extracellular spaces"
-
PGRP-S3 functions as a negative regulator of IMD signaling
"PGRP-S3 likely functions as an extracellular PGN amidase (negative regulator) rather than a transmembrane signaling receptor"
Deep research summary for PGRPS1 in Anopheles gambiae (comparative information)
-
Comparative analysis shows S2/S3 retain catalytic residues while S1 does not
"among short PGRPs (S1, S2, S3), S2/S3 retain catalytic residues (predicted amidases), whereas S1 does not"