Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation by UniProt using UniRule annotation rules
Combined automated annotation of UniProtKB subcellular location terms and UniRule annotation rules
Exoenzyme S of Pseudomonas aeruginosa is secreted by a type III pathway.
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Transposon mutants deficient in exoenzyme S production mapped to a locus whose sequencing revealed exsD followed by eleven ORFs highly similar to the Yersinia YscB-L type III export apparatus, and ExoS export was shown to depend on its amino-terminal residues.
"isolated which exhibited an exoenzyme S-deficient phenotype (388::Tn5Tc 469,"
ExsD is a negative regulator of the Pseudomonas aeruginosa type III secretion regulon.
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A pscC mutant, described as lacking a structural component of the type III translocase, is repressed for expression of the T3SS regulon, and the repression is relieved in a pscC exsD double mutant.
"mutant in pscC, encoding a structural component of the type III translocase, is"
An adenylate cyclase-controlled signaling network regulates Pseudomonas aeruginosa virulence in a mouse model of acute pneumonia.
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A pscC mutant, described as lacking an essential component of the secretion apparatus, is significantly attenuated for lung colonisation and pathology in the mouse pneumonia model.
"exsA gene, which encodes a type III regulatory protein, or pscC, which encodes"
Type III secretion-mediated killing of endothelial cells by Pseudomonas aeruginosa.
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Plasmid insertion mutants in exsA or pscC are significantly less cytotoxic to human umbilical vein endothelial cells than their parents.
"constructed by plasmid insertion in exsA or pscC genes. ExsA is a"
Structural similarity of secretins from type II and type III secretion systems.
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Cell-free-synthesised PscC was purified and imaged by single-particle cryo-EM as a homomultimeric, barrel-like channel with a two-ringed saucer and a plugged central chamber, closely similar to the T2SS secretin PulD.
"The membrane-inserted, multimeric regions of PscC, the"
Outer membrane targeting of Pseudomonas aeruginosa proteins shows variable dependence on the components of Bam and Lol machineries.
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PscC forms multimeric ring-like structures in the outer membrane; its levels fall markedly on LolB depletion but are little affected by reduced BamA, and unlike XcpQ it does not assemble spontaneously into liposomes.
"PilQ, XcpQ, and PscC form multimeric ring-like structures in the OM"
UniProt entry Q9I319 (PA1716, pscC)