GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

PMID:15161933

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.

PMID:19946888

Defining the membrane proteome of NK cells.

PMID:20670374

GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation.

GIGYF2 localizes to endosomal compartments, neuronal perikarya and proximal dendrites, and enhances IGF-1-induced ERK1/2 activation; mutant GIGYF2 did not localize to Lewy bodies.

PMID:20696395

Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes.

The GYF domain of GIGYF2 recognizes proline-rich sequences via a conserved beta-hairpin, mediating its assembly into mRNA-surveillance and vesicular-transport complexes.

PMID:20878056

Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis.

PMID:22681889

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

PMID:22751931

A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.

GIGYF2 directly interacts with m4EHP; this interaction stabilizes both proteins, and disruption of the m4EHP-GIGYF2 complex increases translation and causes perinatal lethality in mice.

PMID:25468996

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

PMID:27157137

Post-transcriptional gene silencing activity of human GIGYF2.

Full-length GIGYF2 coimmunoprecipitates with AGO2 and, when tethered to a reporter mRNA, exhibits strong dose-dependent silencing involving both mRNA destabilization and translational repression.

PMID:28698298

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.

PMID:31439631

Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression.

GIGYF2 interacts directly with EIF4E2 (via the 4EHP-binding motif), with ZFP36/TTP (via P-P-P-P-G repeats), and with DDX6 (via a dedicated motif binding the DDX6 RecA2 domain).

PMID:32726578

GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.

Failed translation triggers GIGYF2/4EHP-mediated inhibition of translation initiation on that message, a negative-feedback RQC mechanism acting in concert with degradation of the stalled nascent polypeptide.

PMID:33053355

4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay.

4EHP-GIGYF1/2 complexes trigger co-translational mRNA decay of transcripts that experience ribosome pausing.

PMID:35271311

OpenCell: Endogenous tagging for the cartography of human cellular organization.

PMID:35878012

SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation.

SARS-CoV-2 nsp2 binds GIGYF2 and enhances GIGYF2-EIF4E2 association to repress translation of IFNB1 mRNA, dampening the type I interferon response.

file:human/GIGYF2/GIGYF2-uniprot.txt

UniProt entry Q6Y7W6 (GGYF2_HUMAN)

file:human/GIGYF2/GIGYF2-goa.tsv

GOA annotations for GIGYF2