SPS19 (YNL202W, UniProt P32573) notes

Module: peroxisomal_beta_oxidation (decr_activity). Missing from YeastCyc YEAST-FAO-PWY.

Evidence journal

• Purified homodimer reduces 2,4-hexadienoyl-CoA to 3-hexenoyl-CoA with NADPH; peroxisomal matrix [PMID:9268358 "converted 2,4-hexadienoyl-CoA into 3-hexenoyl-CoA in an NADPH-dependent manner and therefore contained 2,4-dienoyl-CoA reductase activity."; "Antibodies raised against Sps19p decorated the peroxisomal matrix of oleate-induced cells."].
• sps19 cannot use petroselinate, grows on oleate PMID:9268358; dispensable for sporulation on acetate PMID:9268358.
• Sporulation IMP (PMID:7969036) used a deletion of the shared SPS18/SPS19 promoter PMID:7969036 -> cannot be attributed to SPS19; MARK_AS_OVER_ANNOTATED.
• UniProt: EC 1.3.1.124, (3E)-enoyl-CoA producing; PTS1 SKL [UniProt:P32573].

Curation decisions

• Core MF GO:0008670, BP GO:0009062, CC GO:0005782.
• GO has no unsaturated-fatty-acid beta-oxidation term; suggested question raised.